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PTPROt-mediated regulation of p53/Foxm1 suppresses leukemic phenotype in a CLL mouse model
The gene encoding PTPROt is methylated and suppressed in Chronic Lymphocytc Leukemia. PTPROt exhibits in vitro tumor suppressor characteristics through the regulation of B-cell receptor signaling. Here, we generated transgenic (Tg) mice with B-cell specific expression of PTPROt. While lymphocyte dev...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456291/ https://www.ncbi.nlm.nih.gov/pubmed/25482129 http://dx.doi.org/10.1038/leu.2014.341 |