Cargando…

A Novel 1,4-Dihydropyridine Derivative Improves Spatial Learning and Memory and Modifies Brain Protein Expression in Wild Type and Transgenic APP(SweDI) Mice

Ca(2+) blockers, particularly those capable of crossing the blood-brain barrier (BBB), have been suggested as a possible treatment or disease modifying agents for neurodegenerative disorders, e.g., Alzheimer’s disease. The present study investigated the effects of a novel 4-(N-dodecyl) pyridinium gr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jansone, Baiba, Kadish, Inga, van Groen, Thomas, Beitnere, Ulrika, Moore, Doyle Ray, Plotniece, Aiva, Pajuste, Karlis, Klusa, Vija
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456351/ https://www.ncbi.nlm.nih.gov/pubmed/26042808 http://dx.doi.org/10.1371/journal.pone.0127686

Ejemplares similares

Data for the synthesis and characterisation of 2,6-di(bromomethyl)-3,5-bis(alkoxycarbonyl)-4-aryl-1,4-dihydropyridines as important intermediates for synthesis of amphiphilic 1,4-dihydropyridines
por: Rucins, Martins, et al.
Publicado: (2020)

Pleiotropic Properties of Amphiphilic Dihydropyridines, Dihydropyridones, and Aminovinylcarbonyl Compounds
por: Rucins, Martins, et al.
Publicado: (2020)

Data for the cytotoxicity, self-assembling properties and synthesis of 4-pyridinium-1,4-dihydropyridines
por: Pajuste, Klavs, et al.
Publicado: (2020)

Synthesis and Characterization of Novel Amphiphilic N-Benzyl 1,4-Dihydropyridine Derivatives—Evaluation of Lipid Monolayer and Self-Assembling Properties
por: Krapivina, Anna, et al.
Publicado: (2023)

Evaluation of Physicochemical Properties of Amphiphilic 1,4-Dihydropyridines and Preparation of Magnetoliposomes
por: Petrichenko, Oksana, et al.
Publicado: (2021)

Synthesis of Fluorinated 3,6-Dihydropyridines and 2-(Fluoromethyl)pyridines by Electrophilic Fluorination of 1,2-Dihydropyridines with Selectfluor(®)
por: Pikun, Nadiia V., et al.
Publicado: (2020)

Direct Aminolysis of Ethoxycarbonylmethyl 1,4-Dihydropyridine-3-carboxylates
por: Vigante, Brigita, et al.
Publicado: (2015)

Bactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines
por: Niemirowicz-Laskowska, Katarzyna, et al.
Publicado: (2018)

Contribution of Molecular Structure to Self-Assembling and Biological Properties of Bifunctional Lipid-Like 4-(N-Alkylpyridinium)-1,4-Dihydropyridines
por: Rucins, Martins, et al.
Publicado: (2019)

GABAA agonist muscimol ameliorates learning/memory deficits in streptozocin-induced Alzheimer’s disease non-transgenic rat model
por: Pilipenko, Vladimirs, et al.
Publicado: (2015)

Dihydropyridine Derivatives as Cell Growth Modulators In Vitro
por: Bruvere, Imanta, et al.
Publicado: (2017)

Neuroprotective Properties of Mildronate, a Small Molecule, in a Rat Model of Parkinson’s Disease
por: Klusa, Vija Z., et al.
Publicado: (2010)

Data for characterisation of nanoformulations formed by cationic 1,4-dihydopyridine and calix[4]arene compositions
por: Rucins, Martins, et al.
Publicado: (2022)

Intramolecular C-H···O Hydrogen Bonding in 1,4-Dihydropyridine Derivatives
por: Petrova, Marina, et al.
Publicado: (2011)

Synthesis and Comparative Evaluation of Novel Cationic Amphiphile C12-Man-Q as an Efficient DNA Delivery Agent In Vitro
por: Apsite, Gunita, et al.
Publicado: (2018)

Intranasal Administration of Extracellular Vesicles Derived from Human Teeth Stem Cells Improves Motor Symptoms and Normalizes Tyrosine Hydroxylase Expression in the Substantia Nigra and Striatum of the 6‐Hydroxydopamine‐Treated Rats
por: Narbute, Karīna, et al.
Publicado: (2019)

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice
por: Steffen, Johannes, et al.
Publicado: (2017)

Styrylpyridinium Derivatives for Fluorescent Cell Imaging
por: Putralis, Reinis, et al.
Publicado: (2023)

Design and Synthesis of Hepatitis B Virus (HBV) Capsid Assembly Modulators and Evaluation of Their Activity in Mammalian Cell Model
por: Spunde, Karina, et al.
Publicado: (2022)

Longitudinal investigation of neuroinflammation and metabolite profiles in the APP (swe)×PS1(Δe9) transgenic mouse model of Alzheimer's disease
por: Chaney, Aisling, et al.
Publicado: (2017)

Evodiamine derivatives improve cognitive abilities in APP(swe)/PS1(ΔE9) transgenic mouse models of Alzheimer's disease
por: Pang, Shuo, et al.
Publicado: (2020)

Microglia Express Insulin-Like Growth Factor-1 in the Hippocampus of Aged APP(swe)/PS1(ΔE9) Transgenic Mice
por: Myhre, Christa Løth, et al.
Publicado: (2019)

Effects of rising amyloidβ levels on hippocampal synaptic transmission, microglial response and cognition in APP(Swe)/PSEN1(M146V) transgenic mice
por: Medawar, Evelyn, et al.
Publicado: (2018)

Medium-Dose Chronic Cannabidiol Treatment Reverses Object Recognition Memory Deficits of APP (Swe) /PS1ΔE9 Transgenic Female Mice
por: Coles, Madilyn, et al.
Publicado: (2020)

Intra-Nasally Administered Oligopeptide Lunasin Acts as a Possible Anti-Psychotic Agent in Mice Models
por: Dzirkale, Zane, et al.
Publicado: (2019)

Reliability of the DSS-Swe Questionnaire
por: Jans, Anders, et al.
Publicado: (2023)

Royal jelly peptides: potential inhibitors of β-secretase in N2a/APP695swe cells
por: Zhang, Xueqing, et al.
Publicado: (2019)

Epigenetics in Breast Cancer Therapy—New Strategies and Future Nanomedicine Perspectives
por: Buocikova, Verona, et al.
Publicado: (2020)

Effect of genotype and age on cerebral [(18)F]FDG uptake varies between transgenic APP(Swe)-PS1(dE9) and Tg2576 mouse models of Alzheimer’s disease
por: Snellman, Anniina, et al.
Publicado: (2019)

Age-related changes in synaptic markers and monocyte subsets link the cognitive decline of APP(Swe)/PS1 mice
por: Naert, Gaëlle, et al.
Publicado: (2012)

Enhancing the retrograde axonal transport by curcumin promotes autophagic flux in N2a/APP695swe cells
por: Liang, Jie, et al.
Publicado: (2019)

The Lack of Amyloidogenic Activity Is Persistent in Old WT and APP(swe)/PS1ΔE9 Mouse Retinae
por: Joly, Sandrine, et al.
Publicado: (2021)

Validation of the Swedish Trauma Registry (SweTrau)
por: Holmberg, Lina, et al.
Publicado: (2023)

SweC and SweD are essential co-factors of the FtsEX-CwlO cell wall hydrolase complex in Bacillus subtilis
por: Brunet, Yannick R., et al.
Publicado: (2019)

High efficiency of alphaviral gene transfer in combination with 5-fluorouracil in a mouse mammary tumor model
por: Zajakina, Anna, et al.
Publicado: (2014)

4-Pyridinio-1,4-Dihydropyridines as Calcium Ion Transport Modulators: Antagonist, Agonist, and Dual Action
por: Domracheva, Ilona, et al.
Publicado: (2020)

Diverse Protein Profiles in CNS Myeloid Cells and CNS Tissue From Lipopolysaccharide- and Vehicle-Injected APP(SWE)/PS1(ΔE9) Transgenic Mice Implicate Cathepsin Z in Alzheimer’s Disease
por: Thygesen, Camilla, et al.
Publicado: (2018)

Cdk1 and SUMO Regulate Swe1 Stability
por: Simpson-Lavy, Kobi J., et al.
Publicado: (2010)

Cohort profile: the Swedish Pancreatitis Cohort (SwePan)
por: Selin, Daniel, et al.
Publicado: (2022)

2D-SWE of the Metacarpophalangeal Joint Capsule in Horses
por: Guerri, Giulia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1e7ba7s2f7rm7oug857grknd4u