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A Novel 1,4-Dihydropyridine Derivative Improves Spatial Learning and Memory and Modifies Brain Protein Expression in Wild Type and Transgenic APP(SweDI) Mice
Ca(2+) blockers, particularly those capable of crossing the blood-brain barrier (BBB), have been suggested as a possible treatment or disease modifying agents for neurodegenerative disorders, e.g., Alzheimer’s disease. The present study investigated the effects of a novel 4-(N-dodecyl) pyridinium gr...
Autores principales: | Jansone, Baiba, Kadish, Inga, van Groen, Thomas, Beitnere, Ulrika, Moore, Doyle Ray, Plotniece, Aiva, Pajuste, Karlis, Klusa, Vija |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456351/ https://www.ncbi.nlm.nih.gov/pubmed/26042808 http://dx.doi.org/10.1371/journal.pone.0127686 |
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