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Trypanothione Reductase: A Target Protein for a Combined In Vitro and In Silico Screening Approach

With the goal to identify novel trypanothione reductase (TR) inhibitors, we performed a combination of in vitro and in silico screening approaches. Starting from a highly diverse compound set of 2,816 compounds, 21 novel TR inhibiting compounds could be identified in the initial in vitro screening c...

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Detalles Bibliográficos
Autores principales:	Beig, Mathias, Oellien, Frank, Garoff, Linnéa, Noack, Sandra, Krauth-Siegel, R. Luise, Selzer, Paul M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456413/ https://www.ncbi.nlm.nih.gov/pubmed/26042772 http://dx.doi.org/10.1371/journal.pntd.0003773

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