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Long-term survival and quality of life after intensive care for patients 80 years of age or older

BACKGROUND: Comparison of survival and quality of life in a mixed ICU population of patients 80 years of age or older with a matched segment of the general population. METHODS: We retrospectively analyzed survival of ICU patients ≥80 years admitted to the Haukeland University Hospital in 2000–2012....

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Autores principales: Andersen, Finn H, Flaatten, Hans, Klepstad, Pål, Romild, Ulla, Kvåle, Reidar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Paris 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456598/
https://www.ncbi.nlm.nih.gov/pubmed/26055187
http://dx.doi.org/10.1186/s13613-015-0053-0
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author Andersen, Finn H
Flaatten, Hans
Klepstad, Pål
Romild, Ulla
Kvåle, Reidar
author_facet Andersen, Finn H
Flaatten, Hans
Klepstad, Pål
Romild, Ulla
Kvåle, Reidar
author_sort Andersen, Finn H
collection PubMed
description BACKGROUND: Comparison of survival and quality of life in a mixed ICU population of patients 80 years of age or older with a matched segment of the general population. METHODS: We retrospectively analyzed survival of ICU patients ≥80 years admitted to the Haukeland University Hospital in 2000–2012. We prospectively used the EuroQol-5D to compare the health-related quality of life (HRQOL) between survivors at follow-up and an age- and gender-matched general population. Follow-up was 1–13.8 years. RESULTS: The included 395 patients (mean age 83.8 years, 61.0 % males) showed an overall survival of 75.9 (ICU), 59.5 (hospital), and 42.0 % 1 year after the ICU. High ICU mortality was predicted by age, mechanical ventilator support, SAPS II, maximum SOFA, and multitrauma with head injury. High hospital mortality was predicted by an unplanned surgical admission. One-year mortality was predicted by respiratory failure and isolated head injury. We found no differences in HRQOL at follow-up between survivors (n = 58) and control subjects (n = 179) or between admission categories. Of the ICU non-survivors, 63.2 % died within 2 days after ICU admission (n = 60), and 68.3 % of these had life-sustaining treatment (LST) limitations. LST limitations were applied for 71.3 % (n = 114) of the hospital non-survivors (ICU 70.5 % (n = 67); post-ICU 72.3 % (n = 47)). CONCLUSIONS: Overall 1-year survival was 42.0 %. Survival rates beyond that were comparable to those of the general octogenarian population. Among survivors at follow-up, HRQOL was comparable to that of the age- and sex-matched general population. Patients admitted for planned surgery had better short- and long-term survival rates than those admitted for medical reasons or unplanned surgery for 3 years after ICU admittance. The majority of the ICU non-survivors died within 2 days, and most of these had LST limitation decisions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13613-015-0053-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-44565982015-06-11 Long-term survival and quality of life after intensive care for patients 80 years of age or older Andersen, Finn H Flaatten, Hans Klepstad, Pål Romild, Ulla Kvåle, Reidar Ann Intensive Care Research BACKGROUND: Comparison of survival and quality of life in a mixed ICU population of patients 80 years of age or older with a matched segment of the general population. METHODS: We retrospectively analyzed survival of ICU patients ≥80 years admitted to the Haukeland University Hospital in 2000–2012. We prospectively used the EuroQol-5D to compare the health-related quality of life (HRQOL) between survivors at follow-up and an age- and gender-matched general population. Follow-up was 1–13.8 years. RESULTS: The included 395 patients (mean age 83.8 years, 61.0 % males) showed an overall survival of 75.9 (ICU), 59.5 (hospital), and 42.0 % 1 year after the ICU. High ICU mortality was predicted by age, mechanical ventilator support, SAPS II, maximum SOFA, and multitrauma with head injury. High hospital mortality was predicted by an unplanned surgical admission. One-year mortality was predicted by respiratory failure and isolated head injury. We found no differences in HRQOL at follow-up between survivors (n = 58) and control subjects (n = 179) or between admission categories. Of the ICU non-survivors, 63.2 % died within 2 days after ICU admission (n = 60), and 68.3 % of these had life-sustaining treatment (LST) limitations. LST limitations were applied for 71.3 % (n = 114) of the hospital non-survivors (ICU 70.5 % (n = 67); post-ICU 72.3 % (n = 47)). CONCLUSIONS: Overall 1-year survival was 42.0 %. Survival rates beyond that were comparable to those of the general octogenarian population. Among survivors at follow-up, HRQOL was comparable to that of the age- and sex-matched general population. Patients admitted for planned surgery had better short- and long-term survival rates than those admitted for medical reasons or unplanned surgery for 3 years after ICU admittance. The majority of the ICU non-survivors died within 2 days, and most of these had LST limitation decisions. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13613-015-0053-0) contains supplementary material, which is available to authorized users. Springer Paris 2015-06-03 /pmc/articles/PMC4456598/ /pubmed/26055187 http://dx.doi.org/10.1186/s13613-015-0053-0 Text en © Andersen et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research
Andersen, Finn H
Flaatten, Hans
Klepstad, Pål
Romild, Ulla
Kvåle, Reidar
Long-term survival and quality of life after intensive care for patients 80 years of age or older
title Long-term survival and quality of life after intensive care for patients 80 years of age or older
title_full Long-term survival and quality of life after intensive care for patients 80 years of age or older
title_fullStr Long-term survival and quality of life after intensive care for patients 80 years of age or older
title_full_unstemmed Long-term survival and quality of life after intensive care for patients 80 years of age or older
title_short Long-term survival and quality of life after intensive care for patients 80 years of age or older
title_sort long-term survival and quality of life after intensive care for patients 80 years of age or older
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456598/
https://www.ncbi.nlm.nih.gov/pubmed/26055187
http://dx.doi.org/10.1186/s13613-015-0053-0
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