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Membrane proximal ectodomain cleavage of MUC16 occurs in the acidifying Golgi/post-Golgi compartments

MUC16, precursor of the most widely used ovarian cancer biomarker CA125, is up regulated in multiple malignancies and is associated with poor prognosis. While the pro-tumorigenic and metastatic roles of MUC16 are ascribed to the cell-associated carboxyl-terminal MUC16 (MUC16-Cter), the exact biochem...

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Detalles Bibliográficos
Autores principales:	Das, Srustidhar, Majhi, Prabin D., Al-Mugotir, Mona H., Rachagani, Satyanarayana, Sorgen, Paul, Batra, Surinder K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456727/ https://www.ncbi.nlm.nih.gov/pubmed/26044153 http://dx.doi.org/10.1038/srep09759

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