An unusual occurrence: a case of venous thromboembolism in pregnancy associated with heterotaxy syndrome
BACKGROUND: Heterotaxy is a relatively uncommon congenital anomaly that is usually diagnosed incidentally on imaging studies in adults. We present an unusual case of venous thromboembolism in a 26 year old pregnant female with Heterotaxy syndrome. CASE PRESENTATION: A 26 year-old pregnant female at...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457096/ https://www.ncbi.nlm.nih.gov/pubmed/26052441 http://dx.doi.org/10.1186/s12878-015-0025-5 |
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author | Epperla, Narendranath Peterson, Erika Foy, Patrick |
author_facet | Epperla, Narendranath Peterson, Erika Foy, Patrick |
author_sort | Epperla, Narendranath |
collection | PubMed |
description | BACKGROUND: Heterotaxy is a relatively uncommon congenital anomaly that is usually diagnosed incidentally on imaging studies in adults. We present an unusual case of venous thromboembolism in a 26 year old pregnant female with Heterotaxy syndrome. CASE PRESENTATION: A 26 year-old pregnant female at 13 weeks gestation suffered cardiac arrest with successful cardiac resuscitation and return of spontaneous circulation. The cardiac arrest was secondary to massive pulmonary embolism requiring thrombolytic therapy and stabilization of hemodynamics. She had extensive evaluation to determine the etiology for the pulmonary embolism and was noted to have an anatomic variation consistent with heterotaxy syndrome on imaging studies. After thrombolysis the patient was treated with UFH and then switched to enoxaparin without complication until 25 weeks of gestation when she experienced worsening abdominal pain with associated headaches, lightheadedness and elevated blood pressures needing elective induction of labor. The infant died shortly after delivery. The anticoagulation was continued for additional 3 months and she was subsequently placed on low dose aspirin to prevent recurrent venous thromboembolic episodes. She is currently stable on low dose aspirin and is into her third year after the venous thromboembolism without any recurrence. CONCLUSION: To our knowledge, this is the first reported case of venous thromboembolism in pregnancy associated with heterotaxy syndrome. A discussion on pathophysiology of venous thromboembolism in pregnancy and heterotaxy syndrome has been undertaken along with treatment approach in such situations. |
format | Online Article Text |
id | pubmed-4457096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44570962015-06-06 An unusual occurrence: a case of venous thromboembolism in pregnancy associated with heterotaxy syndrome Epperla, Narendranath Peterson, Erika Foy, Patrick BMC Hematol Case Report BACKGROUND: Heterotaxy is a relatively uncommon congenital anomaly that is usually diagnosed incidentally on imaging studies in adults. We present an unusual case of venous thromboembolism in a 26 year old pregnant female with Heterotaxy syndrome. CASE PRESENTATION: A 26 year-old pregnant female at 13 weeks gestation suffered cardiac arrest with successful cardiac resuscitation and return of spontaneous circulation. The cardiac arrest was secondary to massive pulmonary embolism requiring thrombolytic therapy and stabilization of hemodynamics. She had extensive evaluation to determine the etiology for the pulmonary embolism and was noted to have an anatomic variation consistent with heterotaxy syndrome on imaging studies. After thrombolysis the patient was treated with UFH and then switched to enoxaparin without complication until 25 weeks of gestation when she experienced worsening abdominal pain with associated headaches, lightheadedness and elevated blood pressures needing elective induction of labor. The infant died shortly after delivery. The anticoagulation was continued for additional 3 months and she was subsequently placed on low dose aspirin to prevent recurrent venous thromboembolic episodes. She is currently stable on low dose aspirin and is into her third year after the venous thromboembolism without any recurrence. CONCLUSION: To our knowledge, this is the first reported case of venous thromboembolism in pregnancy associated with heterotaxy syndrome. A discussion on pathophysiology of venous thromboembolism in pregnancy and heterotaxy syndrome has been undertaken along with treatment approach in such situations. BioMed Central 2015-05-12 /pmc/articles/PMC4457096/ /pubmed/26052441 http://dx.doi.org/10.1186/s12878-015-0025-5 Text en © Epperla et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Epperla, Narendranath Peterson, Erika Foy, Patrick An unusual occurrence: a case of venous thromboembolism in pregnancy associated with heterotaxy syndrome |
title | An unusual occurrence: a case of venous thromboembolism in pregnancy associated with heterotaxy syndrome |
title_full | An unusual occurrence: a case of venous thromboembolism in pregnancy associated with heterotaxy syndrome |
title_fullStr | An unusual occurrence: a case of venous thromboembolism in pregnancy associated with heterotaxy syndrome |
title_full_unstemmed | An unusual occurrence: a case of venous thromboembolism in pregnancy associated with heterotaxy syndrome |
title_short | An unusual occurrence: a case of venous thromboembolism in pregnancy associated with heterotaxy syndrome |
title_sort | unusual occurrence: a case of venous thromboembolism in pregnancy associated with heterotaxy syndrome |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457096/ https://www.ncbi.nlm.nih.gov/pubmed/26052441 http://dx.doi.org/10.1186/s12878-015-0025-5 |
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