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A Hypothesis About the Origin of Biology

It is proposed that processes characteristic of biology today, autocatalysis, selection of molecules for linkage by their electrical shape, and evolution by survival selection were also the processes that initiated biology. A reconnaissance is made of both paradoxes and potential questions. It is ar...

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Detalles Bibliográficos
Autor principal: Woolf, Neville J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457165/
https://www.ncbi.nlm.nih.gov/pubmed/25813661
http://dx.doi.org/10.1007/s11084-015-9426-5
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author Woolf, Neville J.
author_facet Woolf, Neville J.
author_sort Woolf, Neville J.
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description It is proposed that processes characteristic of biology today, autocatalysis, selection of molecules for linkage by their electrical shape, and evolution by survival selection were also the processes that initiated biology. A reconnaissance is made of both paradoxes and potential questions. It is argued that the minimal requirement for initiating Darwinian evolution is not a molecule copying process, but a linkage copying process. Survival selection evolution does not require a heterocatalytic polymer and a separate replicase process until there is uncertainty where molecular additions will occur. It is argued that a linkage directing process will be found for a lipid membrane (though this needs to be verified) and may in the right environment result in initial evolution, including initiation of α-helices, the development of a single chirality and NTPs. The system has at this point become sufficiently complex that higher precision copying is needed. However it seems likely that this state is able to generate the first miniature ribozymes and their replicases, and so satisfies the prior requirement. With the proposed requirements, it is likely that the development of polymers was within membranes.
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spelling pubmed-44571652015-06-10 A Hypothesis About the Origin of Biology Woolf, Neville J. Orig Life Evol Biosph Origins 2014 It is proposed that processes characteristic of biology today, autocatalysis, selection of molecules for linkage by their electrical shape, and evolution by survival selection were also the processes that initiated biology. A reconnaissance is made of both paradoxes and potential questions. It is argued that the minimal requirement for initiating Darwinian evolution is not a molecule copying process, but a linkage copying process. Survival selection evolution does not require a heterocatalytic polymer and a separate replicase process until there is uncertainty where molecular additions will occur. It is argued that a linkage directing process will be found for a lipid membrane (though this needs to be verified) and may in the right environment result in initial evolution, including initiation of α-helices, the development of a single chirality and NTPs. The system has at this point become sufficiently complex that higher precision copying is needed. However it seems likely that this state is able to generate the first miniature ribozymes and their replicases, and so satisfies the prior requirement. With the proposed requirements, it is likely that the development of polymers was within membranes. Springer Netherlands 2015-03-27 2015 /pmc/articles/PMC4457165/ /pubmed/25813661 http://dx.doi.org/10.1007/s11084-015-9426-5 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Origins 2014
Woolf, Neville J.
A Hypothesis About the Origin of Biology
title A Hypothesis About the Origin of Biology
title_full A Hypothesis About the Origin of Biology
title_fullStr A Hypothesis About the Origin of Biology
title_full_unstemmed A Hypothesis About the Origin of Biology
title_short A Hypothesis About the Origin of Biology
title_sort hypothesis about the origin of biology
topic Origins 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457165/
https://www.ncbi.nlm.nih.gov/pubmed/25813661
http://dx.doi.org/10.1007/s11084-015-9426-5
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