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A Hypothesis About the Origin of Biology
It is proposed that processes characteristic of biology today, autocatalysis, selection of molecules for linkage by their electrical shape, and evolution by survival selection were also the processes that initiated biology. A reconnaissance is made of both paradoxes and potential questions. It is ar...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Netherlands
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457165/ https://www.ncbi.nlm.nih.gov/pubmed/25813661 http://dx.doi.org/10.1007/s11084-015-9426-5 |
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author | Woolf, Neville J. |
author_facet | Woolf, Neville J. |
author_sort | Woolf, Neville J. |
collection | PubMed |
description | It is proposed that processes characteristic of biology today, autocatalysis, selection of molecules for linkage by their electrical shape, and evolution by survival selection were also the processes that initiated biology. A reconnaissance is made of both paradoxes and potential questions. It is argued that the minimal requirement for initiating Darwinian evolution is not a molecule copying process, but a linkage copying process. Survival selection evolution does not require a heterocatalytic polymer and a separate replicase process until there is uncertainty where molecular additions will occur. It is argued that a linkage directing process will be found for a lipid membrane (though this needs to be verified) and may in the right environment result in initial evolution, including initiation of α-helices, the development of a single chirality and NTPs. The system has at this point become sufficiently complex that higher precision copying is needed. However it seems likely that this state is able to generate the first miniature ribozymes and their replicases, and so satisfies the prior requirement. With the proposed requirements, it is likely that the development of polymers was within membranes. |
format | Online Article Text |
id | pubmed-4457165 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-44571652015-06-10 A Hypothesis About the Origin of Biology Woolf, Neville J. Orig Life Evol Biosph Origins 2014 It is proposed that processes characteristic of biology today, autocatalysis, selection of molecules for linkage by their electrical shape, and evolution by survival selection were also the processes that initiated biology. A reconnaissance is made of both paradoxes and potential questions. It is argued that the minimal requirement for initiating Darwinian evolution is not a molecule copying process, but a linkage copying process. Survival selection evolution does not require a heterocatalytic polymer and a separate replicase process until there is uncertainty where molecular additions will occur. It is argued that a linkage directing process will be found for a lipid membrane (though this needs to be verified) and may in the right environment result in initial evolution, including initiation of α-helices, the development of a single chirality and NTPs. The system has at this point become sufficiently complex that higher precision copying is needed. However it seems likely that this state is able to generate the first miniature ribozymes and their replicases, and so satisfies the prior requirement. With the proposed requirements, it is likely that the development of polymers was within membranes. Springer Netherlands 2015-03-27 2015 /pmc/articles/PMC4457165/ /pubmed/25813661 http://dx.doi.org/10.1007/s11084-015-9426-5 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Origins 2014 Woolf, Neville J. A Hypothesis About the Origin of Biology |
title | A Hypothesis About the Origin of Biology |
title_full | A Hypothesis About the Origin of Biology |
title_fullStr | A Hypothesis About the Origin of Biology |
title_full_unstemmed | A Hypothesis About the Origin of Biology |
title_short | A Hypothesis About the Origin of Biology |
title_sort | hypothesis about the origin of biology |
topic | Origins 2014 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457165/ https://www.ncbi.nlm.nih.gov/pubmed/25813661 http://dx.doi.org/10.1007/s11084-015-9426-5 |
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