Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay

For more than 20 years, reverse pharmacology has been the preeminent strategy to discover the activating ligands of orphan G protein-coupled receptors (GPCRs). The onset of a reverse pharmacology assay is the cloning and subsequent transfection of a GPCR of interest in a cellular expression system....

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Detalles Bibliográficos
Autores principales: Caers, Jelle, Peymen, Katleen, Suetens, Nick, Temmerman, Liesbet, Janssen, Tom, Schoofs, Liliane, Beets, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MyJove Corporation 2014
Materias:
Cellular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457351/
https://www.ncbi.nlm.nih.gov/pubmed/25146596
http://dx.doi.org/10.3791/51516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457351/
https://www.ncbi.nlm.nih.gov/pubmed/25146596
http://dx.doi.org/10.3791/51516

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