Human Kidney Disease-causing INF2 Mutations Perturb Rho/Dia Signaling in the Glomerulus

Mutations in Inverted Formin 2 (INF2), a diaphanous formin family protein that regulates actin cytoskeleton dynamics, cause focal segmental glomerulosclerosis (FSGS) and Charcot–Marie–Tooth Disease (CMT) in humans. In addition to directly remodeling actin filaments in vitro, we have shown that INF2...

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Detalles Bibliográficos
Autores principales: Sun, Hua, Al-Romaih, Khaldoun I., MacRae, Calum A., Pollak, Martin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457406/
https://www.ncbi.nlm.nih.gov/pubmed/26086034
http://dx.doi.org/10.1016/j.ebiom.2014.11.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457406/
https://www.ncbi.nlm.nih.gov/pubmed/26086034
http://dx.doi.org/10.1016/j.ebiom.2014.11.009

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