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Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia

AIMS/HYPOTHESIS: Sirtuin 1 (Sirt1) has been reported to be a critical positive regulator of glucose-stimulated insulin secretion in pancreatic beta-cells. The effects on islet cells and blood glucose levels when Sirt1 is deleted specifically in the pancreas are still unclear. METHODS: This study exa...

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Detalles Bibliográficos
Autores principales:	Pinho, Andreia V., Bensellam, Mohammed, Wauters, Elke, Rees, Maxine, Giry-Laterriere, Marc, Mawson, Amanda, Ly, Le Quan, Biankin, Andrew V., Wu, Jianmin, Laybutt, D. Ross, Rooman, Ilse
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457418/ https://www.ncbi.nlm.nih.gov/pubmed/26046931 http://dx.doi.org/10.1371/journal.pone.0128012

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