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A retrospective observational study of the effectiveness of paliperidone palmitate on acute inpatient hospitalization rates
This retrospective mirror-image observational study aimed to establish the effects of the long-acting antipsychotic injection paliperidone palmitate (PP) on acute inpatient hospitalization rates. We utilized routinely collected clinical data to compare the number and length of acute patient admissio...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams And Wilkins
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457499/ https://www.ncbi.nlm.nih.gov/pubmed/25882381 http://dx.doi.org/10.1097/YIC.0000000000000077 |
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author | Bressington, Daniel Stock, Jon Hulbert, Sabina MacInnes, Douglas |
author_facet | Bressington, Daniel Stock, Jon Hulbert, Sabina MacInnes, Douglas |
author_sort | Bressington, Daniel |
collection | PubMed |
description | This retrospective mirror-image observational study aimed to establish the effects of the long-acting antipsychotic injection paliperidone palmitate (PP) on acute inpatient hospitalization rates. We utilized routinely collected clinical data to compare the number and length of acute patient admissions 1 year before and 1 year after initiation of PP. A single cohort of 66 patients with a diagnosis of schizophrenia and who had received monthly injections of PP for at least 1 year were included in the analysis. The mean number of acute inpatient admissions fell from 0.86 in the year before PP initiation to 0.23 in the following year (P=0.001), and there was a numerical but nonsignificant decrease in the number of bed days from 32.48 to 31.22 over the study duration. The median number of bed days in the year before PP initiation was 20, and in the year after initiation it was 0. The median number of admissions also fell from 1 to 0 during the same period. The results of the study should be treated cautiously because of the limitations of the study design but suggest that patients with a diagnosis of schizophrenia who continue treatment with PP over 12 months experience a significant reduction in hospital admissions compared with the previous year. |
format | Online Article Text |
id | pubmed-4457499 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Lippincott Williams And Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-44574992015-06-19 A retrospective observational study of the effectiveness of paliperidone palmitate on acute inpatient hospitalization rates Bressington, Daniel Stock, Jon Hulbert, Sabina MacInnes, Douglas Int Clin Psychopharmacol Original Articles This retrospective mirror-image observational study aimed to establish the effects of the long-acting antipsychotic injection paliperidone palmitate (PP) on acute inpatient hospitalization rates. We utilized routinely collected clinical data to compare the number and length of acute patient admissions 1 year before and 1 year after initiation of PP. A single cohort of 66 patients with a diagnosis of schizophrenia and who had received monthly injections of PP for at least 1 year were included in the analysis. The mean number of acute inpatient admissions fell from 0.86 in the year before PP initiation to 0.23 in the following year (P=0.001), and there was a numerical but nonsignificant decrease in the number of bed days from 32.48 to 31.22 over the study duration. The median number of bed days in the year before PP initiation was 20, and in the year after initiation it was 0. The median number of admissions also fell from 1 to 0 during the same period. The results of the study should be treated cautiously because of the limitations of the study design but suggest that patients with a diagnosis of schizophrenia who continue treatment with PP over 12 months experience a significant reduction in hospital admissions compared with the previous year. Lippincott Williams And Wilkins 2015-07 2015-06-04 /pmc/articles/PMC4457499/ /pubmed/25882381 http://dx.doi.org/10.1097/YIC.0000000000000077 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0/. |
spellingShingle | Original Articles Bressington, Daniel Stock, Jon Hulbert, Sabina MacInnes, Douglas A retrospective observational study of the effectiveness of paliperidone palmitate on acute inpatient hospitalization rates |
title | A retrospective observational study of the effectiveness of paliperidone palmitate on acute inpatient hospitalization rates |
title_full | A retrospective observational study of the effectiveness of paliperidone palmitate on acute inpatient hospitalization rates |
title_fullStr | A retrospective observational study of the effectiveness of paliperidone palmitate on acute inpatient hospitalization rates |
title_full_unstemmed | A retrospective observational study of the effectiveness of paliperidone palmitate on acute inpatient hospitalization rates |
title_short | A retrospective observational study of the effectiveness of paliperidone palmitate on acute inpatient hospitalization rates |
title_sort | retrospective observational study of the effectiveness of paliperidone palmitate on acute inpatient hospitalization rates |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457499/ https://www.ncbi.nlm.nih.gov/pubmed/25882381 http://dx.doi.org/10.1097/YIC.0000000000000077 |
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