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Glucose-Dependent Insulin Secretion in Pancreatic β-Cell Islets from Male Rats Requires Ca(2+) Release via ROS-Stimulated Ryanodine Receptors
Glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells requires an increase in intracellular free Ca(2+) concentration ([Ca(2+)]). Glucose uptake into β-cells promotes Ca(2+) influx and reactive oxygen species (ROS) generation. In other cell types, Ca(2+) and ROS jointly induce Ca(2+) r...
Autores principales: | Llanos, Paola, Contreras-Ferrat, Ariel, Barrientos, Genaro, Valencia, Marco, Mears, David, Hidalgo, Cecilia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457734/ https://www.ncbi.nlm.nih.gov/pubmed/26046640 http://dx.doi.org/10.1371/journal.pone.0129238 |
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