Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors

The signal peptide peptidases (SPPs) are biomedically important proteases implicated as therapeutic targets for hepatitis C (human SPP, (hSPP)), plasmodium (Plasmodium SPP (pSPP)), and B-cell immunomodulation and neoplasia (signal peptide peptidase like 2a, (SPPL2a)). To date, no drug-like, selectiv...

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Detalles Bibliográficos
Autores principales: Ran, Yong, Ladd, Gabriela Z., Ceballos-Diaz, Carolina, Jung, Joo In, Greenbaum, Doron, Felsenstein, Kevin M., Golde, Todd E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457840/
https://www.ncbi.nlm.nih.gov/pubmed/26046535
http://dx.doi.org/10.1371/journal.pone.0128619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457840/
https://www.ncbi.nlm.nih.gov/pubmed/26046535
http://dx.doi.org/10.1371/journal.pone.0128619

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