Effect of Pore Size and Porosity on the Biomechanical Properties and Cytocompatibility of Porous NiTi Alloys

Five types of porous Nickel-Titanium (NiTi) alloy samples of different porosities and pore sizes were fabricated. According to compressive and fracture strengths, three groups of porous NiTi alloy samples underwent further cytocompatibility experiments. Porous NiTi alloys exhibited a lower Young’s m...

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Autores principales: Jian, Yu-Tao, Yang, Yue, Tian, Tian, Stanford, Clark, Zhang, Xin-Ping, Zhao, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457866/
https://www.ncbi.nlm.nih.gov/pubmed/26047515
http://dx.doi.org/10.1371/journal.pone.0128138
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author Jian, Yu-Tao
Yang, Yue
Tian, Tian
Stanford, Clark
Zhang, Xin-Ping
Zhao, Ke
author_facet Jian, Yu-Tao
Yang, Yue
Tian, Tian
Stanford, Clark
Zhang, Xin-Ping
Zhao, Ke
author_sort Jian, Yu-Tao
collection PubMed
description Five types of porous Nickel-Titanium (NiTi) alloy samples of different porosities and pore sizes were fabricated. According to compressive and fracture strengths, three groups of porous NiTi alloy samples underwent further cytocompatibility experiments. Porous NiTi alloys exhibited a lower Young’s modulus (2.0 GPa ~ 0.8 GPa). Both compressive strength (108.8 MPa ~ 56.2 MPa) and fracture strength (64.6 MPa ~ 41.6 MPa) decreased gradually with increasing mean pore size (MPS). Cells grew and spread well on all porous NiTi alloy samples. Cells attached more strongly on control group and blank group than on all porous NiTi alloy samples (p < 0.05). Cell adhesion on porous NiTi alloys was correlated negatively to MPS (277.2 μm ~ 566.5 μm; p < 0.05). More cells proliferated on control group and blank group than on all porous NiTi alloy samples (p < 0.05). Cellular ALP activity on all porous NiTi alloy samples was higher than on control group and blank group (p < 0.05). The porous NiTi alloys with optimized pore size could be a potential orthopedic material.
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spelling pubmed-44578662015-06-09 Effect of Pore Size and Porosity on the Biomechanical Properties and Cytocompatibility of Porous NiTi Alloys Jian, Yu-Tao Yang, Yue Tian, Tian Stanford, Clark Zhang, Xin-Ping Zhao, Ke PLoS One Research Article Five types of porous Nickel-Titanium (NiTi) alloy samples of different porosities and pore sizes were fabricated. According to compressive and fracture strengths, three groups of porous NiTi alloy samples underwent further cytocompatibility experiments. Porous NiTi alloys exhibited a lower Young’s modulus (2.0 GPa ~ 0.8 GPa). Both compressive strength (108.8 MPa ~ 56.2 MPa) and fracture strength (64.6 MPa ~ 41.6 MPa) decreased gradually with increasing mean pore size (MPS). Cells grew and spread well on all porous NiTi alloy samples. Cells attached more strongly on control group and blank group than on all porous NiTi alloy samples (p < 0.05). Cell adhesion on porous NiTi alloys was correlated negatively to MPS (277.2 μm ~ 566.5 μm; p < 0.05). More cells proliferated on control group and blank group than on all porous NiTi alloy samples (p < 0.05). Cellular ALP activity on all porous NiTi alloy samples was higher than on control group and blank group (p < 0.05). The porous NiTi alloys with optimized pore size could be a potential orthopedic material. Public Library of Science 2015-06-05 /pmc/articles/PMC4457866/ /pubmed/26047515 http://dx.doi.org/10.1371/journal.pone.0128138 Text en © 2015 Jian et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Jian, Yu-Tao
Yang, Yue
Tian, Tian
Stanford, Clark
Zhang, Xin-Ping
Zhao, Ke
Effect of Pore Size and Porosity on the Biomechanical Properties and Cytocompatibility of Porous NiTi Alloys
title Effect of Pore Size and Porosity on the Biomechanical Properties and Cytocompatibility of Porous NiTi Alloys
title_full Effect of Pore Size and Porosity on the Biomechanical Properties and Cytocompatibility of Porous NiTi Alloys
title_fullStr Effect of Pore Size and Porosity on the Biomechanical Properties and Cytocompatibility of Porous NiTi Alloys
title_full_unstemmed Effect of Pore Size and Porosity on the Biomechanical Properties and Cytocompatibility of Porous NiTi Alloys
title_short Effect of Pore Size and Porosity on the Biomechanical Properties and Cytocompatibility of Porous NiTi Alloys
title_sort effect of pore size and porosity on the biomechanical properties and cytocompatibility of porous niti alloys
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457866/
https://www.ncbi.nlm.nih.gov/pubmed/26047515
http://dx.doi.org/10.1371/journal.pone.0128138
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