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All-Trans Retinoic Acid Activity in Acute Myeloid Leukemia: Role of Cytochrome P450 Enzyme Expression by the Microenvironment

Differentiation therapy with all-trans retinoic acid (atRA) has markedly improved outcome in acute promyelocytic leukemia (APL) but has had little clinical impact in other AML sub-types. Cell intrinsic mechanisms of resistance have been previously reported, yet the majority of AML blasts are sensiti...

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Detalles Bibliográficos
Autores principales:	Su, Meng, Alonso, Salvador, Jones, Jace W., Yu, Jianshi, Kane, Maureen A., Jones, Richard J., Ghiaur, Gabriel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457893/ https://www.ncbi.nlm.nih.gov/pubmed/26047326 http://dx.doi.org/10.1371/journal.pone.0127790

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