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Blood flow mechanics in cardiovascular development
Hemodynamic forces are fundamental to development. Indeed, much of cardiovascular morphogenesis reflects a two-way interaction between mechanical forces and the gene network activated in endothelial cells via mechanotransduction feedback loops. As these interactions are becoming better understood in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Basel
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457920/ https://www.ncbi.nlm.nih.gov/pubmed/25801176 http://dx.doi.org/10.1007/s00018-015-1885-3 |
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author | Boselli, Francesco Freund, Jonathan B. Vermot, Julien |
author_facet | Boselli, Francesco Freund, Jonathan B. Vermot, Julien |
author_sort | Boselli, Francesco |
collection | PubMed |
description | Hemodynamic forces are fundamental to development. Indeed, much of cardiovascular morphogenesis reflects a two-way interaction between mechanical forces and the gene network activated in endothelial cells via mechanotransduction feedback loops. As these interactions are becoming better understood in different model organisms, it is possible to identify common mechanogenetic rules, which are strikingly conserved and shared in many tissues and species. Here, we discuss recent findings showing how hemodynamic forces potentially modulate cardiovascular development as well as the underlying fluid and tissue mechanics, with special attention given to the flow characteristics that are unique to the small scales of embryos. |
format | Online Article Text |
id | pubmed-4457920 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Springer Basel |
record_format | MEDLINE/PubMed |
spelling | pubmed-44579202015-06-11 Blood flow mechanics in cardiovascular development Boselli, Francesco Freund, Jonathan B. Vermot, Julien Cell Mol Life Sci Review Hemodynamic forces are fundamental to development. Indeed, much of cardiovascular morphogenesis reflects a two-way interaction between mechanical forces and the gene network activated in endothelial cells via mechanotransduction feedback loops. As these interactions are becoming better understood in different model organisms, it is possible to identify common mechanogenetic rules, which are strikingly conserved and shared in many tissues and species. Here, we discuss recent findings showing how hemodynamic forces potentially modulate cardiovascular development as well as the underlying fluid and tissue mechanics, with special attention given to the flow characteristics that are unique to the small scales of embryos. Springer Basel 2015-03-24 2015 /pmc/articles/PMC4457920/ /pubmed/25801176 http://dx.doi.org/10.1007/s00018-015-1885-3 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Review Boselli, Francesco Freund, Jonathan B. Vermot, Julien Blood flow mechanics in cardiovascular development |
title | Blood flow mechanics in cardiovascular development |
title_full | Blood flow mechanics in cardiovascular development |
title_fullStr | Blood flow mechanics in cardiovascular development |
title_full_unstemmed | Blood flow mechanics in cardiovascular development |
title_short | Blood flow mechanics in cardiovascular development |
title_sort | blood flow mechanics in cardiovascular development |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457920/ https://www.ncbi.nlm.nih.gov/pubmed/25801176 http://dx.doi.org/10.1007/s00018-015-1885-3 |
work_keys_str_mv | AT bosellifrancesco bloodflowmechanicsincardiovasculardevelopment AT freundjonathanb bloodflowmechanicsincardiovasculardevelopment AT vermotjulien bloodflowmechanicsincardiovasculardevelopment |