Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans

ABSTRACT: During inflammation, the kynurenine pathway (KP) metabolises the essential amino acid tryptophan (TRP) potentially contributing to excitotoxicity via the release of quinolinic acid (QUIN) and 3-hydroxykynurenine (3HK). Despite the importance of excitotoxicity in the development of secondar...

Descripción completa

Detalles Bibliográficos
Autores principales: Yan, Edwin B., Frugier, Tony, Lim, Chai K., Heng, Benjamin, Sundaram, Gayathri, Tan, May, Rosenfeld, Jeffrey V., Walker, David W., Guillemin, Gilles J., Morganti-Kossmann, Maria Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457980/
https://www.ncbi.nlm.nih.gov/pubmed/26025142
http://dx.doi.org/10.1186/s12974-015-0328-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457980/
https://www.ncbi.nlm.nih.gov/pubmed/26025142
http://dx.doi.org/10.1186/s12974-015-0328-2

Ejemplares similares