Identification and selective expansion of functionally superior T cells expressing chimeric antigen receptors

BACKGROUND: T cells expressing chimeric antigen receptors (CARs) have shown exciting promise in cancer therapy, particularly in the treatment of B-cell malignancies. However, optimization of CAR-T cell production remains a trial-and-error exercise due to a lack of phenotypic benchmarks that are clea...

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Detalles Bibliográficos
Autores principales: Chang, ZeNan L., Silver, Pamela A., Chen, Yvonne Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4457995/
https://www.ncbi.nlm.nih.gov/pubmed/25990251
http://dx.doi.org/10.1186/s12967-015-0519-8

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