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Prognostic significance of c-Met in breast cancer: a meta-analysis of 6010 cases

BACKGROUND: The prognostic value of c-Met in breast cancer remains controversial. A meta-analysis of the impact of c-Met in breast cancer was performed by searching published data. METHODS: Published studies analyzing overall survival (OS) or relapse free survival (RFS) according to c-Met expression...

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Autores principales: Yan, Shunchao, Jiao, Xin, Zou, Huawei, Li, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458003/
https://www.ncbi.nlm.nih.gov/pubmed/26047809
http://dx.doi.org/10.1186/s13000-015-0296-y
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author Yan, Shunchao
Jiao, Xin
Zou, Huawei
Li, Kai
author_facet Yan, Shunchao
Jiao, Xin
Zou, Huawei
Li, Kai
author_sort Yan, Shunchao
collection PubMed
description BACKGROUND: The prognostic value of c-Met in breast cancer remains controversial. A meta-analysis of the impact of c-Met in breast cancer was performed by searching published data. METHODS: Published studies analyzing overall survival (OS) or relapse free survival (RFS) according to c-Met expression were searched. The principal outcome measures were hazard ratios (HRs) for RFS or OS according to c-Met expression. Combined HRs were calculated using fixed- or random- effects models according to the heterogeneity. RESULTS: Twenty-one studies involving 6,010 patients met our selection criteria. The impact of c-Met on RFS and OS was investigated in 12 and 17 studies, respectively. The meta-analysis results showed that c-Met overexpression significantly predicted poor RFS and OS in unselected breast cancer. Subgroup analysis indicated that c-Met overexpression was correlated with poor RFS and OS in Western patients, but was not associated with RFS or OS in Asian patients. C-Met was associated with poor OS in lymph node negative breast cancer and with poor RFS in hormone-receptor positive and triple negative breast cancer, but was not associated with prognosis in human epidermal growth factor receptor (HER)-2 positive breast cancer. CONCLUSIONS: C-Met overexpression is an adverse prognostic marker in breast cancer, except among Asian and HER-2 positive patients. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1869780799156041
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spelling pubmed-44580032015-06-07 Prognostic significance of c-Met in breast cancer: a meta-analysis of 6010 cases Yan, Shunchao Jiao, Xin Zou, Huawei Li, Kai Diagn Pathol Research BACKGROUND: The prognostic value of c-Met in breast cancer remains controversial. A meta-analysis of the impact of c-Met in breast cancer was performed by searching published data. METHODS: Published studies analyzing overall survival (OS) or relapse free survival (RFS) according to c-Met expression were searched. The principal outcome measures were hazard ratios (HRs) for RFS or OS according to c-Met expression. Combined HRs were calculated using fixed- or random- effects models according to the heterogeneity. RESULTS: Twenty-one studies involving 6,010 patients met our selection criteria. The impact of c-Met on RFS and OS was investigated in 12 and 17 studies, respectively. The meta-analysis results showed that c-Met overexpression significantly predicted poor RFS and OS in unselected breast cancer. Subgroup analysis indicated that c-Met overexpression was correlated with poor RFS and OS in Western patients, but was not associated with RFS or OS in Asian patients. C-Met was associated with poor OS in lymph node negative breast cancer and with poor RFS in hormone-receptor positive and triple negative breast cancer, but was not associated with prognosis in human epidermal growth factor receptor (HER)-2 positive breast cancer. CONCLUSIONS: C-Met overexpression is an adverse prognostic marker in breast cancer, except among Asian and HER-2 positive patients. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1869780799156041 BioMed Central 2015-06-06 /pmc/articles/PMC4458003/ /pubmed/26047809 http://dx.doi.org/10.1186/s13000-015-0296-y Text en © Yan et al. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Yan, Shunchao
Jiao, Xin
Zou, Huawei
Li, Kai
Prognostic significance of c-Met in breast cancer: a meta-analysis of 6010 cases
title Prognostic significance of c-Met in breast cancer: a meta-analysis of 6010 cases
title_full Prognostic significance of c-Met in breast cancer: a meta-analysis of 6010 cases
title_fullStr Prognostic significance of c-Met in breast cancer: a meta-analysis of 6010 cases
title_full_unstemmed Prognostic significance of c-Met in breast cancer: a meta-analysis of 6010 cases
title_short Prognostic significance of c-Met in breast cancer: a meta-analysis of 6010 cases
title_sort prognostic significance of c-met in breast cancer: a meta-analysis of 6010 cases
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458003/
https://www.ncbi.nlm.nih.gov/pubmed/26047809
http://dx.doi.org/10.1186/s13000-015-0296-y
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