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Homocysteine thiolactone and N-homocysteinylated protein induce pro-atherogenic changes in gene expression in human vascular endothelial cells
Genetic or nutritional deficiencies in homocysteine (Hcy) metabolism lead to hyperhomocysteinemia (HHcy) and cause endothelial dysfunction, a hallmark of atherosclerosis. In addition to Hcy, related metabolites accumulate in HHcy but their role in endothelial dysfunction is unknown. Here, we examine...
Autores principales: | Gurda, Dorota, Handschuh, Luiza, Kotkowiak, Weronika, Jakubowski, Hieronim |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Vienna
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458266/ https://www.ncbi.nlm.nih.gov/pubmed/25802182 http://dx.doi.org/10.1007/s00726-015-1956-7 |
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