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Homocysteine thiolactone and N-homocysteinylated protein induce pro-atherogenic changes in gene expression in human vascular endothelial cells

Genetic or nutritional deficiencies in homocysteine (Hcy) metabolism lead to hyperhomocysteinemia (HHcy) and cause endothelial dysfunction, a hallmark of atherosclerosis. In addition to Hcy, related metabolites accumulate in HHcy but their role in endothelial dysfunction is unknown. Here, we examine...

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Detalles Bibliográficos
Autores principales: Gurda, Dorota, Handschuh, Luiza, Kotkowiak, Weronika, Jakubowski, Hieronim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458266/
https://www.ncbi.nlm.nih.gov/pubmed/25802182
http://dx.doi.org/10.1007/s00726-015-1956-7

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