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The Role of the Right Dorsolateral Prefrontal Cortex in Phasic Alertness: Evidence from a Contingent Negative Variation and Repetitive Transcranial Magnetic Stimulation Study
Phasic alertness represents the ability to increase response readiness to a target following an external warning stimulus. Specific networks in the frontal and parietal regions appear to be involved in the alert state. In this study, we examined the role of the right dorsolateral prefrontal cortex (...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458283/ https://www.ncbi.nlm.nih.gov/pubmed/26090234 http://dx.doi.org/10.1155/2015/410785 |
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author | Mannarelli, Daniela Pauletti, Caterina Grippo, Antonello Amantini, Aldo Augugliaro, Vito Currà, Antonio Missori, Paolo Locuratolo, Nicoletta De Lucia, Maria C. Rinalduzzi, Steno Fattapposta, Francesco |
author_facet | Mannarelli, Daniela Pauletti, Caterina Grippo, Antonello Amantini, Aldo Augugliaro, Vito Currà, Antonio Missori, Paolo Locuratolo, Nicoletta De Lucia, Maria C. Rinalduzzi, Steno Fattapposta, Francesco |
author_sort | Mannarelli, Daniela |
collection | PubMed |
description | Phasic alertness represents the ability to increase response readiness to a target following an external warning stimulus. Specific networks in the frontal and parietal regions appear to be involved in the alert state. In this study, we examined the role of the right dorsolateral prefrontal cortex (DLPFC) during the attentional processing of a stimulus using a cued double-choice reaction time task. The evaluation of these processes was conducted by means of Event-Related Potentials (ERPs), in particular by using the Contingent Negative Variation (CNV), and repetitive 1-Hz Transcranial Magnetic Stimulation (rTMS). Transient virtual inhibition of the right DLPFC induced by real 1-Hz rTMS stimulation led to a significant decrease in total CNV and W1-CNV areas if compared with the basal and post-sham rTMS conditions. Reaction times (RTs) did not decrease after inhibitory rTMS, but they did improve after sham stimulation. These results suggest that the right DLPFC plays a crucial role in the genesis and maintenance of the alerting state and learning processes. |
format | Online Article Text |
id | pubmed-4458283 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-44582832015-06-18 The Role of the Right Dorsolateral Prefrontal Cortex in Phasic Alertness: Evidence from a Contingent Negative Variation and Repetitive Transcranial Magnetic Stimulation Study Mannarelli, Daniela Pauletti, Caterina Grippo, Antonello Amantini, Aldo Augugliaro, Vito Currà, Antonio Missori, Paolo Locuratolo, Nicoletta De Lucia, Maria C. Rinalduzzi, Steno Fattapposta, Francesco Neural Plast Research Article Phasic alertness represents the ability to increase response readiness to a target following an external warning stimulus. Specific networks in the frontal and parietal regions appear to be involved in the alert state. In this study, we examined the role of the right dorsolateral prefrontal cortex (DLPFC) during the attentional processing of a stimulus using a cued double-choice reaction time task. The evaluation of these processes was conducted by means of Event-Related Potentials (ERPs), in particular by using the Contingent Negative Variation (CNV), and repetitive 1-Hz Transcranial Magnetic Stimulation (rTMS). Transient virtual inhibition of the right DLPFC induced by real 1-Hz rTMS stimulation led to a significant decrease in total CNV and W1-CNV areas if compared with the basal and post-sham rTMS conditions. Reaction times (RTs) did not decrease after inhibitory rTMS, but they did improve after sham stimulation. These results suggest that the right DLPFC plays a crucial role in the genesis and maintenance of the alerting state and learning processes. Hindawi Publishing Corporation 2015 2015-05-24 /pmc/articles/PMC4458283/ /pubmed/26090234 http://dx.doi.org/10.1155/2015/410785 Text en Copyright © 2015 Daniela Mannarelli et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Mannarelli, Daniela Pauletti, Caterina Grippo, Antonello Amantini, Aldo Augugliaro, Vito Currà, Antonio Missori, Paolo Locuratolo, Nicoletta De Lucia, Maria C. Rinalduzzi, Steno Fattapposta, Francesco The Role of the Right Dorsolateral Prefrontal Cortex in Phasic Alertness: Evidence from a Contingent Negative Variation and Repetitive Transcranial Magnetic Stimulation Study |
title | The Role of the Right Dorsolateral Prefrontal Cortex in Phasic Alertness: Evidence from a Contingent Negative Variation and Repetitive Transcranial Magnetic Stimulation Study |
title_full | The Role of the Right Dorsolateral Prefrontal Cortex in Phasic Alertness: Evidence from a Contingent Negative Variation and Repetitive Transcranial Magnetic Stimulation Study |
title_fullStr | The Role of the Right Dorsolateral Prefrontal Cortex in Phasic Alertness: Evidence from a Contingent Negative Variation and Repetitive Transcranial Magnetic Stimulation Study |
title_full_unstemmed | The Role of the Right Dorsolateral Prefrontal Cortex in Phasic Alertness: Evidence from a Contingent Negative Variation and Repetitive Transcranial Magnetic Stimulation Study |
title_short | The Role of the Right Dorsolateral Prefrontal Cortex in Phasic Alertness: Evidence from a Contingent Negative Variation and Repetitive Transcranial Magnetic Stimulation Study |
title_sort | role of the right dorsolateral prefrontal cortex in phasic alertness: evidence from a contingent negative variation and repetitive transcranial magnetic stimulation study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458283/ https://www.ncbi.nlm.nih.gov/pubmed/26090234 http://dx.doi.org/10.1155/2015/410785 |
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