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Impact of Volatile Anesthetics on Oxidative Stress and Inflammation

The safety of anesthesia, which is an important step for surgery, can be determined by its impact on oxidative stress and inflammation. The effects of volatile anesthetics such as isoflurane and sevoflurane on oxidative stress and inflammation are reviewed in various (1) cell lines, (2) rodents, and...

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Autores principales: Lee, Yoon-Mi, Song, Byeng Chun, Yeum, Kyung-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458520/
https://www.ncbi.nlm.nih.gov/pubmed/26101769
http://dx.doi.org/10.1155/2015/242709
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author Lee, Yoon-Mi
Song, Byeng Chun
Yeum, Kyung-Jin
author_facet Lee, Yoon-Mi
Song, Byeng Chun
Yeum, Kyung-Jin
author_sort Lee, Yoon-Mi
collection PubMed
description The safety of anesthesia, which is an important step for surgery, can be determined by its impact on oxidative stress and inflammation. The effects of volatile anesthetics such as isoflurane and sevoflurane on oxidative stress and inflammation are reviewed in various (1) cell lines, (2) rodents, and (3) human studies. Isoflurane and sevoflurane are reported to have antioxidant and anti-inflammatory effects in all cells with exception of neuronal cell lines. In addition, various animal studies have indicated that isoflurane and sevoflurane were not only safe but also reduced oxidative stress and inflammation in rodent models. In human studies, oxidative stress, inflammation, and DNA damage were not affected by isoflurane and sevoflurane in patients undergoing minor incision surgeries. On the other hand, elevated oxidative stress, inflammation, and DNA damage have been observed in patients undergoing major surgeries such as abdominal and orthopedic surgeries, hysterectomy, cholecystectomy, and thoracotomy. Although impact of anesthetics on oxidative stress and inflammation is still not clear due to the variations of patients' health conditions, types of surgery and the quantities of anesthetics, isoflurane, and sevoflurane can be considered safe anesthetics with respect to their effect on oxidative stress and inflammation in subjects undergoing minor surgery. Continuous effort evaluating the safety of anesthesia in various aspects is required.
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spelling pubmed-44585202015-06-22 Impact of Volatile Anesthetics on Oxidative Stress and Inflammation Lee, Yoon-Mi Song, Byeng Chun Yeum, Kyung-Jin Biomed Res Int Review Article The safety of anesthesia, which is an important step for surgery, can be determined by its impact on oxidative stress and inflammation. The effects of volatile anesthetics such as isoflurane and sevoflurane on oxidative stress and inflammation are reviewed in various (1) cell lines, (2) rodents, and (3) human studies. Isoflurane and sevoflurane are reported to have antioxidant and anti-inflammatory effects in all cells with exception of neuronal cell lines. In addition, various animal studies have indicated that isoflurane and sevoflurane were not only safe but also reduced oxidative stress and inflammation in rodent models. In human studies, oxidative stress, inflammation, and DNA damage were not affected by isoflurane and sevoflurane in patients undergoing minor incision surgeries. On the other hand, elevated oxidative stress, inflammation, and DNA damage have been observed in patients undergoing major surgeries such as abdominal and orthopedic surgeries, hysterectomy, cholecystectomy, and thoracotomy. Although impact of anesthetics on oxidative stress and inflammation is still not clear due to the variations of patients' health conditions, types of surgery and the quantities of anesthetics, isoflurane, and sevoflurane can be considered safe anesthetics with respect to their effect on oxidative stress and inflammation in subjects undergoing minor surgery. Continuous effort evaluating the safety of anesthesia in various aspects is required. Hindawi Publishing Corporation 2015 2015-05-25 /pmc/articles/PMC4458520/ /pubmed/26101769 http://dx.doi.org/10.1155/2015/242709 Text en Copyright © 2015 Yoon-Mi Lee et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lee, Yoon-Mi
Song, Byeng Chun
Yeum, Kyung-Jin
Impact of Volatile Anesthetics on Oxidative Stress and Inflammation
title Impact of Volatile Anesthetics on Oxidative Stress and Inflammation
title_full Impact of Volatile Anesthetics on Oxidative Stress and Inflammation
title_fullStr Impact of Volatile Anesthetics on Oxidative Stress and Inflammation
title_full_unstemmed Impact of Volatile Anesthetics on Oxidative Stress and Inflammation
title_short Impact of Volatile Anesthetics on Oxidative Stress and Inflammation
title_sort impact of volatile anesthetics on oxidative stress and inflammation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458520/
https://www.ncbi.nlm.nih.gov/pubmed/26101769
http://dx.doi.org/10.1155/2015/242709
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