Metallothionein-I/II Knockout Mice Aggravate Mitochondrial Superoxide Production and Peroxiredoxin 3 Expression in Thyroid after Excessive Iodide Exposure

Purpose. We aim to figure out the effect of metallothioneins on iodide excess induced oxidative stress in the thyroid. Methods. Eight-week-old MT-I/II knockout (MT-I/II KO) mice and background-matched wild-type (WT) mice were used. Mitochondrial superoxide production and peroxiredoxin (Prx) 3 expres...

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Detalles Bibliográficos
Autores principales: Zhang, Na, Wang, Lingyan, Duan, Qi, Lin, Laixiang, Ahmed, Mohamed, Wang, Tingting, Yao, Xiaomei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458558/
https://www.ncbi.nlm.nih.gov/pubmed/26101557
http://dx.doi.org/10.1155/2015/267027

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