Cargando…

Divalent metal transporter 1 (DMT1) in the brain: implications for a role in iron transport at the blood-brain barrier, and neuronal and glial pathology

Iron is required in a variety of essential processes in the body. In this review, we focus on iron transport in the brain and the role of the divalent metal transporter 1 (DMT1) vital for iron uptake in most cells. DMT1 locates to cellular membranes and endosomal membranes, where it is a key player...

Descripción completa

Detalles Bibliográficos
Autores principales:	Skjørringe, Tina, Burkhart, Annette, Johnsen, Kasper Bendix, Moos, Torben
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2015
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458610/ https://www.ncbi.nlm.nih.gov/pubmed/26106291 http://dx.doi.org/10.3389/fnmol.2015.00019

Ejemplares similares

Blood–Brain Barrier Transport of Transferrin Receptor-Targeted Nanoparticles
por: Thomsen, Maj Schneider, et al.
Publicado: (2022)

Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma
por: Johnsen, Kasper Bendix, et al.
Publicado: (2017)

A role for divalent metal transporter (DMT1) in mitochondrial uptake of iron and manganese
por: Wolff , Natascha A., et al.
Publicado: (2018)

Mathematical modeling of the relocation of the divalent metal transporter DMT1 in the intestinal iron absorption process
por: Cegarra, Layimar, et al.
Publicado: (2019)

Iron deficiency and iron treatment in the fetal developing brain – a pilot study introducing an experimental rat model
por: Moos, Torben, et al.
Publicado: (2018)

Characterization of Divalent Metal Transporter 1 (DMT1) in Brugia malayi suggests an intestinal-associated pathway for iron absorption
por: Ballesteros, Cristina, et al.
Publicado: (2018)

Impairment of Interrelated Iron- and Copper Homeostatic Mechanisms in Brain Contributes to the Pathogenesis of Neurodegenerative Disorders
por: Skjørringe, Tina, et al.
Publicado: (2012)

(52)Mn Production for PET/MRI Tracking Of Human Stem Cells Expressing Divalent Metal Transporter 1 (DMT1)
por: Lewis, Christina M., et al.
Publicado: (2015)

A direct comparison of divalent metal-ion transporter (DMT1) and hinokitiol, a potential small molecule replacement
por: Garrick, Michael D., et al.
Publicado: (2019)

A Triple Culture Model of the Blood-Brain Barrier Using Porcine Brain Endothelial cells, Astrocytes and Pericytes
por: Thomsen, Louiza Bohn, et al.
Publicado: (2015)

Iron deposits in the chronically inflamed central nervous system and contributes to neurodegeneration
por: Andersen, Hjalte Holm, et al.
Publicado: (2013)

Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver
por: Foot, Natalie J., et al.
Publicado: (2016)

Identification and Functional Verification of MicroRNA-16 Family Targeting Intestinal Divalent Metal Transporter 1 (DMT1) in vitro and in vivo
por: Jiang, Shuxia, et al.
Publicado: (2019)

Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles
por: Johnsen, Kasper Bendix, et al.
Publicado: (2018)

Transgenic Mice Overexpressing the Divalent Metal Transporter 1 Exhibit Iron Accumulation and Enhanced Parkin Expression in the Brain
por: Zhang, Cheng-Wu, et al.
Publicado: (2017)

Protoporphyrin IX regulates peripheral benzodiazepine receptor associated protein 7 (PAP7) and divalent metal transporter 1 (DMT1) in K562 cells
por: Okazaki, Yasumasa, et al.
Publicado: (2017)

The blood-brain barrier studied in vitro across species
por: Thomsen, Maj Schneider, et al.
Publicado: (2021)

Glucose Transporter 1 and Monocarboxylate Transporters 1, 2, and 4 Localization within the Glial Cells of Shark Blood-Brain-Barriers
por: Balmaceda-Aguilera, Carolina, et al.
Publicado: (2012)

Transfection of brain capillary endothelial cells in primary culture with defined blood–brain barrier properties
por: Burkhart, Annette, et al.
Publicado: (2015)

Dictyostelium Nramp1, which is structurally and functionally similar to mammalian DMT1 transporter, mediates phagosomal iron efflux
por: Buracco, Simona, et al.
Publicado: (2015)

Control of Systemic Iron Homeostasis by the 3’ Iron-Responsive Element of Divalent Metal Transporter 1 in Mice
por: Tybl, Elisabeth, et al.
Publicado: (2020)

Deficiency of Calcium-Independent Phospholipase A2 Beta Induces Brain Iron Accumulation through Upregulation of Divalent Metal Transporter 1
por: Beck, Goichi, et al.
Publicado: (2015)

Iron Transport from Ferrous Bisglycinate and Ferrous Sulfate in DMT1-Knockout Human Intestinal Caco-2 Cells
por: Yu, Xiaonan, et al.
Publicado: (2019)

Plasmodium yoelii iron transporter PyDMT1 interacts with host ferritin and is required in full activity for malarial pathogenesis
por: Zhong, Mengjiao, et al.
Publicado: (2023)

Regulation of divalent metal transporter-1 by serine phosphorylation
por: Seo, Young Ah, et al.
Publicado: (2016)

Post-capillary venules are the key locus for transcytosis-mediated brain delivery of therapeutic nanoparticles
por: Kucharz, Krzysztof, et al.
Publicado: (2021)

Inhibitors of Human Divalent Metal Transporters DMT1 (SLC11A2) and ZIP8 (SLC39A8) from a GDB‐17 Fragment Library
por: Pujol‐Giménez, Jonai, et al.
Publicado: (2021)

The Endolysosomal Transporter DMT1 is Required for Morphine Regulation of Neuronal Ferritin Heavy Chain
por: Irollo, Elena, et al.
Publicado: (2023)

A novel strategy for delivering Niemann‐Pick type C2 proteins across the blood–brain barrier using the brain endothelial‐specific AAV‐BR1 virus
por: Rasmussen, Charlotte Laurfelt Munch, et al.
Publicado: (2022)

Cadmium Transport in a Model of Neonatal Intestinal Cells Correlates to MRP1 and Not DMT1 or FPN1
por: Öhrvik, Helena, et al.
Publicado: (2013)

DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration
por: Ingrassia, Rosaria, et al.
Publicado: (2019)

Antioxidant Effect of Propofol in Gliomas and Its Association With Divalent Metal Transporter 1
por: Yang, Chenyi, et al.
Publicado: (2020)

Catgut implantation at acupoints increases the expression of glutamate aspartate transporter and glial glutamate transporter-1 in the brain of rats with spasticity after stroke
por: Li, Rui-Qing, et al.
Publicado: (2018)

Iron Overload Is Associated With Accelerated Progression of Osteoarthritis: The Role of DMT1 Mediated Iron Homeostasis
por: Jing, Xingzhi, et al.
Publicado: (2021)

Glial influence on the Blood Brain Barrier
por: Alvarez, Jorge Ivan, et al.
Publicado: (2013)

Iron Transporters and Ferroptosis in Malignant Brain Tumors
por: Zhao, Jingyu, et al.
Publicado: (2022)

Circulating ECVs prevent neurodegeneration and preserve neuronal function in a model of preclinical intracerebral hemorrhage
por: Burkhart, Annette, et al.
Publicado: (2023)

Transport of Glial Cell Line-Derived Neurotrophic Factor into Liposomes across the Blood-Brain Barrier: In Vitro and in Vivo Studies
por: Wu, Shaoling, et al.
Publicado: (2014)

Imperatorin is Transported through Blood-Brain Barrier by Carrier-Mediated Transporters
por: Tun, Temdara, et al.
Publicado: (2017)

Brain-transportable dipeptides across the blood-brain barrier in mice
por: Tanaka, Mitsuru, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_eol03m72b5gn8h7sfe91cvh323