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Perinatal risk factors for premature ischaemic heart disease in a Swedish national cohort
OBJECTIVE: Several studies have reported associations between restricted fetal development, as shown by birth weight or birth length, and later ischaemic heart disease (IHD). However, few studies have examined the importance of these perinatal factors when taking into account gestational age at birt...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458615/ https://www.ncbi.nlm.nih.gov/pubmed/26038357 http://dx.doi.org/10.1136/bmjopen-2014-007308 |
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author | Zöller, Bengt Sundquist, Jan Sundquist, Kristina Crump, Casey |
author_facet | Zöller, Bengt Sundquist, Jan Sundquist, Kristina Crump, Casey |
author_sort | Zöller, Bengt |
collection | PubMed |
description | OBJECTIVE: Several studies have reported associations between restricted fetal development, as shown by birth weight or birth length, and later ischaemic heart disease (IHD). However, few studies have examined the importance of these perinatal factors when taking into account gestational age at birth, hereditary factors, sociodemographic factors and comorbidities. This study investigated the importance of perinatal risk factors for premature IHD and myocardial infarction (MI) in a large Swedish cohort. SETTING AND PARTICIPANTS: National cohort study of 1 970 869 individuals who were live-born in Sweden in 1973 through 1992, and followed up to 2010 (ages 18–38 years). PRIMARY AND SECONDARY OUTCOME MEASURES: The main outcome was IHD, and the secondary outcome was MI. RESULTS: A total of 668 individuals were diagnosed with IHD in 18.8 million person-years of follow-up. After adjusting for gestational age at birth, sociodemographic factors, comorbidities and family history of IHD, low fetal growth was associated with increased risk of IHD (HR for <−2 vs −1 to <1 SD, 1.54; 95% CI 1.15 to 2.07; p=0.004) and increased risk of MI (HR for <−2 vs −1 to <1 SD, 2.48; 95% CI 1.66 to 3.71; p<0.001) in young adulthood. In contrast, gestational age at birth was not associated with the risk of IHD or MI. CONCLUSIONS: In this large national cohort, low fetal growth was strongly associated with IHD and MI in young adulthood, independently of gestational age at birth, sociodemographic factors, comorbidities and family history of IHD. |
format | Online Article Text |
id | pubmed-4458615 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-44586152015-06-10 Perinatal risk factors for premature ischaemic heart disease in a Swedish national cohort Zöller, Bengt Sundquist, Jan Sundquist, Kristina Crump, Casey BMJ Open Epidemiology OBJECTIVE: Several studies have reported associations between restricted fetal development, as shown by birth weight or birth length, and later ischaemic heart disease (IHD). However, few studies have examined the importance of these perinatal factors when taking into account gestational age at birth, hereditary factors, sociodemographic factors and comorbidities. This study investigated the importance of perinatal risk factors for premature IHD and myocardial infarction (MI) in a large Swedish cohort. SETTING AND PARTICIPANTS: National cohort study of 1 970 869 individuals who were live-born in Sweden in 1973 through 1992, and followed up to 2010 (ages 18–38 years). PRIMARY AND SECONDARY OUTCOME MEASURES: The main outcome was IHD, and the secondary outcome was MI. RESULTS: A total of 668 individuals were diagnosed with IHD in 18.8 million person-years of follow-up. After adjusting for gestational age at birth, sociodemographic factors, comorbidities and family history of IHD, low fetal growth was associated with increased risk of IHD (HR for <−2 vs −1 to <1 SD, 1.54; 95% CI 1.15 to 2.07; p=0.004) and increased risk of MI (HR for <−2 vs −1 to <1 SD, 2.48; 95% CI 1.66 to 3.71; p<0.001) in young adulthood. In contrast, gestational age at birth was not associated with the risk of IHD or MI. CONCLUSIONS: In this large national cohort, low fetal growth was strongly associated with IHD and MI in young adulthood, independently of gestational age at birth, sociodemographic factors, comorbidities and family history of IHD. BMJ Publishing Group 2015-06-02 /pmc/articles/PMC4458615/ /pubmed/26038357 http://dx.doi.org/10.1136/bmjopen-2014-007308 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Epidemiology Zöller, Bengt Sundquist, Jan Sundquist, Kristina Crump, Casey Perinatal risk factors for premature ischaemic heart disease in a Swedish national cohort |
title | Perinatal risk factors for premature ischaemic heart disease in a Swedish national cohort |
title_full | Perinatal risk factors for premature ischaemic heart disease in a Swedish national cohort |
title_fullStr | Perinatal risk factors for premature ischaemic heart disease in a Swedish national cohort |
title_full_unstemmed | Perinatal risk factors for premature ischaemic heart disease in a Swedish national cohort |
title_short | Perinatal risk factors for premature ischaemic heart disease in a Swedish national cohort |
title_sort | perinatal risk factors for premature ischaemic heart disease in a swedish national cohort |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458615/ https://www.ncbi.nlm.nih.gov/pubmed/26038357 http://dx.doi.org/10.1136/bmjopen-2014-007308 |
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