Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report

• Primary vaginal clear cell adenocarcinoma (PVCCA) coexists with urinary tract anomalies without exposure to diethylstilbestrol in some cases. • PVCCA in our case showed genetic alterations of well-known cancer related genes, including a mutation of PIK3CA. • The genetic profile suggests that the c...

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Detalles Bibliográficos
Autores principales: Ikeda, Yuji, Oda, Katsutoshi, Aburatani, Hiroyuki, Kawana, Kei, Osuga, Yutaka, Fujii, Tomoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458747/
https://www.ncbi.nlm.nih.gov/pubmed/26082939
http://dx.doi.org/10.1016/j.gynor.2014.05.006
Descripción
Sumario:• Primary vaginal clear cell adenocarcinoma (PVCCA) coexists with urinary tract anomalies without exposure to diethylstilbestrol in some cases. • PVCCA in our case showed genetic alterations of well-known cancer related genes, including a mutation of PIK3CA. • The genetic profile suggests that the carcinogenesis of PVCCA might have elements common with that of OCCA.

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