Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report

• Primary vaginal clear cell adenocarcinoma (PVCCA) coexists with urinary tract anomalies without exposure to diethylstilbestrol in some cases. • PVCCA in our case showed genetic alterations of well-known cancer related genes, including a mutation of PIK3CA. • The genetic profile suggests that the c...

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Autores principales: Ikeda, Yuji, Oda, Katsutoshi, Aburatani, Hiroyuki, Kawana, Kei, Osuga, Yutaka, Fujii, Tomoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458747/
https://www.ncbi.nlm.nih.gov/pubmed/26082939
http://dx.doi.org/10.1016/j.gynor.2014.05.006
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author Ikeda, Yuji
Oda, Katsutoshi
Aburatani, Hiroyuki
Kawana, Kei
Osuga, Yutaka
Fujii, Tomoyuki
author_facet Ikeda, Yuji
Oda, Katsutoshi
Aburatani, Hiroyuki
Kawana, Kei
Osuga, Yutaka
Fujii, Tomoyuki
author_sort Ikeda, Yuji
collection PubMed
description • Primary vaginal clear cell adenocarcinoma (PVCCA) coexists with urinary tract anomalies without exposure to diethylstilbestrol in some cases. • PVCCA in our case showed genetic alterations of well-known cancer related genes, including a mutation of PIK3CA. • The genetic profile suggests that the carcinogenesis of PVCCA might have elements common with that of OCCA.
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spelling pubmed-44587472015-06-16 Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report Ikeda, Yuji Oda, Katsutoshi Aburatani, Hiroyuki Kawana, Kei Osuga, Yutaka Fujii, Tomoyuki Gynecol Oncol Rep Case Report • Primary vaginal clear cell adenocarcinoma (PVCCA) coexists with urinary tract anomalies without exposure to diethylstilbestrol in some cases. • PVCCA in our case showed genetic alterations of well-known cancer related genes, including a mutation of PIK3CA. • The genetic profile suggests that the carcinogenesis of PVCCA might have elements common with that of OCCA. Elsevier 2014-06-05 /pmc/articles/PMC4458747/ /pubmed/26082939 http://dx.doi.org/10.1016/j.gynor.2014.05.006 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Case Report
Ikeda, Yuji
Oda, Katsutoshi
Aburatani, Hiroyuki
Kawana, Kei
Osuga, Yutaka
Fujii, Tomoyuki
Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report
title Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report
title_full Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report
title_fullStr Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report
title_full_unstemmed Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report
title_short Non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: A case report
title_sort non-diethylstilbestrol exposed vaginal clear cell adenocarcinoma has a common molecular profile with ovarian clear cell adenocarcinoma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458747/
https://www.ncbi.nlm.nih.gov/pubmed/26082939
http://dx.doi.org/10.1016/j.gynor.2014.05.006
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