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Dengue Seroprevalence in the French West Indies: A Prospective Study in Adult Blood Donors

Using an anti-dengue immunoglobulin G (IgG) indirect enzyme-linked immunosorbent assay, seroprevalence was determined among 783 adult blood donors in the French Caribbean islands of Guadeloupe and Martinique in 2011. Overall, 93.5% [91.5; 95.1] samples were positive for dengue antibodies, 90.7% (350...

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Autores principales: L'Azou, Maïna, Jean-Marie, Janick, Bessaud, Maël, Cabié, André, Césaire, Raymond, de Lamballerie, Xavier, Courbil, Rémi, Richard, Pascale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458816/
https://www.ncbi.nlm.nih.gov/pubmed/25846291
http://dx.doi.org/10.4269/ajtmh.14-0211
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author L'Azou, Maïna
Jean-Marie, Janick
Bessaud, Maël
Cabié, André
Césaire, Raymond
de Lamballerie, Xavier
Courbil, Rémi
Richard, Pascale
author_facet L'Azou, Maïna
Jean-Marie, Janick
Bessaud, Maël
Cabié, André
Césaire, Raymond
de Lamballerie, Xavier
Courbil, Rémi
Richard, Pascale
author_sort L'Azou, Maïna
collection PubMed
description Using an anti-dengue immunoglobulin G (IgG) indirect enzyme-linked immunosorbent assay, seroprevalence was determined among 783 adult blood donors in the French Caribbean islands of Guadeloupe and Martinique in 2011. Overall, 93.5% [91.5; 95.1] samples were positive for dengue antibodies, 90.7% (350 of 386) in Martinique and 96.2% (382 of 397) in Guadeloupe. Only 30% of these adults recalled having had dengue disease before. Serotype-specific neutralization assays applied to a subset of IgG-positive samples indicated that a majority (77 of 96; 80%) reacted to the four serotypes. These seroprevalence findings are the first reported for Guadeloupe and Martinique and are consistent with the dengue epidemiology in these territories.
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spelling pubmed-44588162015-06-11 Dengue Seroprevalence in the French West Indies: A Prospective Study in Adult Blood Donors L'Azou, Maïna Jean-Marie, Janick Bessaud, Maël Cabié, André Césaire, Raymond de Lamballerie, Xavier Courbil, Rémi Richard, Pascale Am J Trop Med Hyg Articles Using an anti-dengue immunoglobulin G (IgG) indirect enzyme-linked immunosorbent assay, seroprevalence was determined among 783 adult blood donors in the French Caribbean islands of Guadeloupe and Martinique in 2011. Overall, 93.5% [91.5; 95.1] samples were positive for dengue antibodies, 90.7% (350 of 386) in Martinique and 96.2% (382 of 397) in Guadeloupe. Only 30% of these adults recalled having had dengue disease before. Serotype-specific neutralization assays applied to a subset of IgG-positive samples indicated that a majority (77 of 96; 80%) reacted to the four serotypes. These seroprevalence findings are the first reported for Guadeloupe and Martinique and are consistent with the dengue epidemiology in these territories. The American Society of Tropical Medicine and Hygiene 2015-06-03 /pmc/articles/PMC4458816/ /pubmed/25846291 http://dx.doi.org/10.4269/ajtmh.14-0211 Text en ©The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Articles
L'Azou, Maïna
Jean-Marie, Janick
Bessaud, Maël
Cabié, André
Césaire, Raymond
de Lamballerie, Xavier
Courbil, Rémi
Richard, Pascale
Dengue Seroprevalence in the French West Indies: A Prospective Study in Adult Blood Donors
title Dengue Seroprevalence in the French West Indies: A Prospective Study in Adult Blood Donors
title_full Dengue Seroprevalence in the French West Indies: A Prospective Study in Adult Blood Donors
title_fullStr Dengue Seroprevalence in the French West Indies: A Prospective Study in Adult Blood Donors
title_full_unstemmed Dengue Seroprevalence in the French West Indies: A Prospective Study in Adult Blood Donors
title_short Dengue Seroprevalence in the French West Indies: A Prospective Study in Adult Blood Donors
title_sort dengue seroprevalence in the french west indies: a prospective study in adult blood donors
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458816/
https://www.ncbi.nlm.nih.gov/pubmed/25846291
http://dx.doi.org/10.4269/ajtmh.14-0211
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