Functional topography of the human entorhinal cortex

Despite extensive research on the role of the rodent medial and lateral entorhinal cortex (MEC/LEC) in spatial navigation, memory and related disease, their human homologues remain elusive. Here, we combine high-field functional magnetic resonance imaging at 7 T with novel data-driven and model-base...

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Autores principales: Navarro Schröder, Tobias, Haak, Koen V, Zaragoza Jimenez, Nestor I, Beckmann, Christian F, Doeller, Christian F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458840/
https://www.ncbi.nlm.nih.gov/pubmed/26052748
http://dx.doi.org/10.7554/eLife.06738
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author Navarro Schröder, Tobias
Haak, Koen V
Zaragoza Jimenez, Nestor I
Beckmann, Christian F
Doeller, Christian F
author_facet Navarro Schröder, Tobias
Haak, Koen V
Zaragoza Jimenez, Nestor I
Beckmann, Christian F
Doeller, Christian F
author_sort Navarro Schröder, Tobias
collection PubMed
description Despite extensive research on the role of the rodent medial and lateral entorhinal cortex (MEC/LEC) in spatial navigation, memory and related disease, their human homologues remain elusive. Here, we combine high-field functional magnetic resonance imaging at 7 T with novel data-driven and model-based analyses to identify corresponding subregions in humans based on the well-known global connectivity fingerprints in rodents and sensitivity to spatial and non-spatial information. We provide evidence for a functional division primarily along the anteroposterior axis. Localising the human homologue of the rodent MEC and LEC has important implications for translating studies on the hippocampo-entorhinal memory system from rodents to humans. DOI: http://dx.doi.org/10.7554/eLife.06738.001
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spelling pubmed-44588402015-06-10 Functional topography of the human entorhinal cortex Navarro Schröder, Tobias Haak, Koen V Zaragoza Jimenez, Nestor I Beckmann, Christian F Doeller, Christian F eLife Neuroscience Despite extensive research on the role of the rodent medial and lateral entorhinal cortex (MEC/LEC) in spatial navigation, memory and related disease, their human homologues remain elusive. Here, we combine high-field functional magnetic resonance imaging at 7 T with novel data-driven and model-based analyses to identify corresponding subregions in humans based on the well-known global connectivity fingerprints in rodents and sensitivity to spatial and non-spatial information. We provide evidence for a functional division primarily along the anteroposterior axis. Localising the human homologue of the rodent MEC and LEC has important implications for translating studies on the hippocampo-entorhinal memory system from rodents to humans. DOI: http://dx.doi.org/10.7554/eLife.06738.001 eLife Sciences Publications, Ltd 2015-06-08 /pmc/articles/PMC4458840/ /pubmed/26052748 http://dx.doi.org/10.7554/eLife.06738 Text en © 2015, Navarro Schröder et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Navarro Schröder, Tobias
Haak, Koen V
Zaragoza Jimenez, Nestor I
Beckmann, Christian F
Doeller, Christian F
Functional topography of the human entorhinal cortex
title Functional topography of the human entorhinal cortex
title_full Functional topography of the human entorhinal cortex
title_fullStr Functional topography of the human entorhinal cortex
title_full_unstemmed Functional topography of the human entorhinal cortex
title_short Functional topography of the human entorhinal cortex
title_sort functional topography of the human entorhinal cortex
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458840/
https://www.ncbi.nlm.nih.gov/pubmed/26052748
http://dx.doi.org/10.7554/eLife.06738
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