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Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint

The spindle assembly checkpoint (SAC) ensures proper chromosome segregation by delaying anaphase onset in response to unattached kinetochores. Checkpoint signalling requires the kinetochore localization of the Mad1–Mad2 complex that in more complex eukaryotes depends on the Rod–Zwilch–ZW10 (RZZ) com...

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Detalles Bibliográficos
Autores principales:	Zhang, Gang, Lischetti, Tiziana, Hayward, Daniel G., Nilsson, Jakob
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4458899/ https://www.ncbi.nlm.nih.gov/pubmed/26031201 http://dx.doi.org/10.1038/ncomms8162

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