Comparative analysis of Rb1, P16 and ER as diagnostic, prognostic and potential targets for therapeutic agents in ovarian epithelial tumors: an immunohistochemical study of 130 ovarian carcinomas

BACKGROUND: Deregulation of CDK4/6, cyclin D/P16 and retinoblastoma (Rb) are known aberrations in certain malignancies. There has been a recent interest in exploring the combination of letrozole and CDK4/6 inhibitors in recurrent ER+ ovarian cancers. METHODS: This study aimed to determine the freque...

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Detalles Bibliográficos
Autores principales: Ferguson, Donna Catherine, Long, Daniel Jerad, Smith, Megan Christine, Craig-Owens, Laura Deeanne, Means, Julie, Fadare, Oluwole, Desouki, Mohamed Mokhtar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459058/
https://www.ncbi.nlm.nih.gov/pubmed/26043844
http://dx.doi.org/10.1186/s13048-015-0163-1

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