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TCR-Signaling Events in Cellular Metabolism and Specialization

Engaging the T cell receptor (TCR) with peptide:MHC complexes initiates a cascade of signaling events that activates T cells in an antigen-specific manner. It is now clear that multiple inputs, including the strength of TCR signaling, co-stimulation, and the cytokine environment, impact T cell speci...

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Detalles Bibliográficos
Autores principales: Chisolm, Danielle A., Weinmann, Amy S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459085/
https://www.ncbi.nlm.nih.gov/pubmed/26106392
http://dx.doi.org/10.3389/fimmu.2015.00292
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author Chisolm, Danielle A.
Weinmann, Amy S.
author_facet Chisolm, Danielle A.
Weinmann, Amy S.
author_sort Chisolm, Danielle A.
collection PubMed
description Engaging the T cell receptor (TCR) with peptide:MHC complexes initiates a cascade of signaling events that activates T cells in an antigen-specific manner. It is now clear that multiple inputs, including the strength of TCR signaling, co-stimulation, and the cytokine environment, impact T cell specialization decisions in the context of specific pathogenic encounters. Additionally, it is now appreciated that these same stimuli direct cellular metabolism programs. In this review, we will discuss how TCR-signaling events coordinate cellular metabolism and specialization gene programs in T cells.
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spelling pubmed-44590852015-06-23 TCR-Signaling Events in Cellular Metabolism and Specialization Chisolm, Danielle A. Weinmann, Amy S. Front Immunol Immunology Engaging the T cell receptor (TCR) with peptide:MHC complexes initiates a cascade of signaling events that activates T cells in an antigen-specific manner. It is now clear that multiple inputs, including the strength of TCR signaling, co-stimulation, and the cytokine environment, impact T cell specialization decisions in the context of specific pathogenic encounters. Additionally, it is now appreciated that these same stimuli direct cellular metabolism programs. In this review, we will discuss how TCR-signaling events coordinate cellular metabolism and specialization gene programs in T cells. Frontiers Media S.A. 2015-06-08 /pmc/articles/PMC4459085/ /pubmed/26106392 http://dx.doi.org/10.3389/fimmu.2015.00292 Text en Copyright © 2015 Chisolm and Weinmann. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chisolm, Danielle A.
Weinmann, Amy S.
TCR-Signaling Events in Cellular Metabolism and Specialization
title TCR-Signaling Events in Cellular Metabolism and Specialization
title_full TCR-Signaling Events in Cellular Metabolism and Specialization
title_fullStr TCR-Signaling Events in Cellular Metabolism and Specialization
title_full_unstemmed TCR-Signaling Events in Cellular Metabolism and Specialization
title_short TCR-Signaling Events in Cellular Metabolism and Specialization
title_sort tcr-signaling events in cellular metabolism and specialization
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459085/
https://www.ncbi.nlm.nih.gov/pubmed/26106392
http://dx.doi.org/10.3389/fimmu.2015.00292
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