Structural and Dynamic Features of F-recruitment Site Driven Substrate Phosphorylation by ERK2

The F-recruitment site (FRS) of active ERK2 binds F-site (Phe-x-Phe-Pro) sequences found downstream of the Ser/Thr phospho-acceptor on cellular substrates. Here we apply NMR methods to analyze the interaction between active ERK2 (ppERK2), and a 13-residue F-site-bearing peptide substrate derived fro...

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Detalles Bibliográficos
Autores principales: Piserchio, Andrea, Ramakrishan, Venkatesh, Wang, Hsin, Kaoud, Tamer S., Arshava, Boris, Dutta, Kaushik, Dalby, Kevin N., Ghose, Ranajeet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459106/
https://www.ncbi.nlm.nih.gov/pubmed/26054059
http://dx.doi.org/10.1038/srep11127

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