Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers

Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabili...

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Autores principales: Zhang, Wei, Luo, Xiao-juan, Niu, Li-na, Yang, Hong-ye, Yiu, Cynthia K.Y., Wang, Tian-da, Zhou, Li-qun, Mao, Jing, Huang, Cui, Pashley, David H., Tay, Franklin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459175/
https://www.ncbi.nlm.nih.gov/pubmed/26053330
http://dx.doi.org/10.1038/srep11199
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author Zhang, Wei
Luo, Xiao-juan
Niu, Li-na
Yang, Hong-ye
Yiu, Cynthia K.Y.
Wang, Tian-da
Zhou, Li-qun
Mao, Jing
Huang, Cui
Pashley, David H.
Tay, Franklin R.
author_facet Zhang, Wei
Luo, Xiao-juan
Niu, Li-na
Yang, Hong-ye
Yiu, Cynthia K.Y.
Wang, Tian-da
Zhou, Li-qun
Mao, Jing
Huang, Cui
Pashley, David H.
Tay, Franklin R.
author_sort Zhang, Wei
collection PubMed
description Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabilized amorphous calcium phosphate precursors. Both two-dimensional and three-dimensional collagen models can be intrafibrillarly mineralized with these released fluidic intermediate precursors. This represents an important advance in the translation of biomineralization concepts into regimes for in-situ remineralization of bone and teeth.
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spelling pubmed-44591752015-06-17 Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers Zhang, Wei Luo, Xiao-juan Niu, Li-na Yang, Hong-ye Yiu, Cynthia K.Y. Wang, Tian-da Zhou, Li-qun Mao, Jing Huang, Cui Pashley, David H. Tay, Franklin R. Sci Rep Article Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabilized amorphous calcium phosphate precursors. Both two-dimensional and three-dimensional collagen models can be intrafibrillarly mineralized with these released fluidic intermediate precursors. This represents an important advance in the translation of biomineralization concepts into regimes for in-situ remineralization of bone and teeth. Nature Publishing Group 2015-06-08 /pmc/articles/PMC4459175/ /pubmed/26053330 http://dx.doi.org/10.1038/srep11199 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, Wei
Luo, Xiao-juan
Niu, Li-na
Yang, Hong-ye
Yiu, Cynthia K.Y.
Wang, Tian-da
Zhou, Li-qun
Mao, Jing
Huang, Cui
Pashley, David H.
Tay, Franklin R.
Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers
title Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers
title_full Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers
title_fullStr Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers
title_full_unstemmed Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers
title_short Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers
title_sort biomimetic intrafibrillar mineralization of type i collagen with intermediate precursors-loaded mesoporous carriers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459175/
https://www.ncbi.nlm.nih.gov/pubmed/26053330
http://dx.doi.org/10.1038/srep11199
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