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Effects of hypertonic saline and mannitol on cortical cerebral microcirculation in a rabbit craniotomy model

BACKGROUND: Hyperosmolar solutions have been used in neurosurgery to modify brain bulk and prevent neurological deterioration. The aim of this animal study was to compare the short-term effects of equivolemic, equiosmolar solutions of mannitol and hypertonic saline (HTS) on cerebral cortical microci...

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Autores principales: Dostal, Pavel, Schreiberova, Jitka, Dostalova, Vlasta, Tyll, Tomas, Paral, Jiri, Abdo, Islam, Cihlo, Miroslav, Astapenko, David, Turek, Zdenek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459466/
https://www.ncbi.nlm.nih.gov/pubmed/26055873
http://dx.doi.org/10.1186/s12871-015-0067-z
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author Dostal, Pavel
Schreiberova, Jitka
Dostalova, Vlasta
Dostalova, Vlasta
Tyll, Tomas
Paral, Jiri
Abdo, Islam
Cihlo, Miroslav
Astapenko, David
Turek, Zdenek
author_facet Dostal, Pavel
Schreiberova, Jitka
Dostalova, Vlasta
Dostalova, Vlasta
Tyll, Tomas
Paral, Jiri
Abdo, Islam
Cihlo, Miroslav
Astapenko, David
Turek, Zdenek
author_sort Dostal, Pavel
collection PubMed
description BACKGROUND: Hyperosmolar solutions have been used in neurosurgery to modify brain bulk and prevent neurological deterioration. The aim of this animal study was to compare the short-term effects of equivolemic, equiosmolar solutions of mannitol and hypertonic saline (HTS) on cerebral cortical microcirculation in a rabbit craniotomy model. METHODS: Rabbits (weight, 2.0–3.0 kg) were anesthetized, ventilated mechanically, and subjected to a craniotomy. The animals were allocated randomly to receive a 3.75 ml/kg intravenous infusion of either 3.2 % HTS (group HTS, n = 8) or 20 % mannitol (group MTL, n = 8). Microcirculation in the cerebral cortex was evaluated using sidestream dark-field (SDF) imaging before and 20 min after the end of the 15-min HTS infusion. Global hemodynamic data were recorded, and blood samples for laboratory analysis were obtained at the time of SDF image recording. RESULTS: No differences in the microcirculatory parameters were observed between the groups before the use of osmotherapy. After osmotherapy, lower proportions of perfused small vessel density (P = 0.0474), perfused vessel density (P = 0.0457), and microvascular flow index (P = 0.0207) were observed in the MTL group compared with those in the HTS group. CONCLUSIONS: Our findings suggest that an equivolemic, equiosmolar HTS solution better preserves perfusion of cortical brain microcirculation compared to MTL in a rabbit craniotomy model.
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spelling pubmed-44594662015-06-09 Effects of hypertonic saline and mannitol on cortical cerebral microcirculation in a rabbit craniotomy model Dostal, Pavel Schreiberova, Jitka Dostalova, Vlasta Dostalova, Vlasta Tyll, Tomas Paral, Jiri Abdo, Islam Cihlo, Miroslav Astapenko, David Turek, Zdenek BMC Anesthesiol Research Article BACKGROUND: Hyperosmolar solutions have been used in neurosurgery to modify brain bulk and prevent neurological deterioration. The aim of this animal study was to compare the short-term effects of equivolemic, equiosmolar solutions of mannitol and hypertonic saline (HTS) on cerebral cortical microcirculation in a rabbit craniotomy model. METHODS: Rabbits (weight, 2.0–3.0 kg) were anesthetized, ventilated mechanically, and subjected to a craniotomy. The animals were allocated randomly to receive a 3.75 ml/kg intravenous infusion of either 3.2 % HTS (group HTS, n = 8) or 20 % mannitol (group MTL, n = 8). Microcirculation in the cerebral cortex was evaluated using sidestream dark-field (SDF) imaging before and 20 min after the end of the 15-min HTS infusion. Global hemodynamic data were recorded, and blood samples for laboratory analysis were obtained at the time of SDF image recording. RESULTS: No differences in the microcirculatory parameters were observed between the groups before the use of osmotherapy. After osmotherapy, lower proportions of perfused small vessel density (P = 0.0474), perfused vessel density (P = 0.0457), and microvascular flow index (P = 0.0207) were observed in the MTL group compared with those in the HTS group. CONCLUSIONS: Our findings suggest that an equivolemic, equiosmolar HTS solution better preserves perfusion of cortical brain microcirculation compared to MTL in a rabbit craniotomy model. BioMed Central 2015-06-09 /pmc/articles/PMC4459466/ /pubmed/26055873 http://dx.doi.org/10.1186/s12871-015-0067-z Text en © Dostal et al. 2015 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Dostal, Pavel
Schreiberova, Jitka
Dostalova, Vlasta
Dostalova, Vlasta
Tyll, Tomas
Paral, Jiri
Abdo, Islam
Cihlo, Miroslav
Astapenko, David
Turek, Zdenek
Effects of hypertonic saline and mannitol on cortical cerebral microcirculation in a rabbit craniotomy model
title Effects of hypertonic saline and mannitol on cortical cerebral microcirculation in a rabbit craniotomy model
title_full Effects of hypertonic saline and mannitol on cortical cerebral microcirculation in a rabbit craniotomy model
title_fullStr Effects of hypertonic saline and mannitol on cortical cerebral microcirculation in a rabbit craniotomy model
title_full_unstemmed Effects of hypertonic saline and mannitol on cortical cerebral microcirculation in a rabbit craniotomy model
title_short Effects of hypertonic saline and mannitol on cortical cerebral microcirculation in a rabbit craniotomy model
title_sort effects of hypertonic saline and mannitol on cortical cerebral microcirculation in a rabbit craniotomy model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459466/
https://www.ncbi.nlm.nih.gov/pubmed/26055873
http://dx.doi.org/10.1186/s12871-015-0067-z
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