Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome

Rheumatoid arthritis (RA) remains a debilitating autoimmune condition as many patients are refractory to existing conventional and biologic therapies, and hence successful development of novel treatments remains a critical requirement. Towards this, we now describe a synthetic drug-like small molecu...

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Detalles Bibliográficos
Autores principales: Rzepecka, Justyna, Pineda, Miguel A., Al-Riyami, Lamyaa, Rodgers, David T., Huggan, Judith K., Lumb, Felicity E., Khalaf, Abedawn I., Meakin, Paul J., Corbet, Marlene, Ashford, Michael L., Suckling, Colin J., Harnett, Margaret M., Harnett, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459730/
https://www.ncbi.nlm.nih.gov/pubmed/25975491
http://dx.doi.org/10.1016/j.jaut.2015.04.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459730/
https://www.ncbi.nlm.nih.gov/pubmed/25975491
http://dx.doi.org/10.1016/j.jaut.2015.04.005

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