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Proteomic and microRNA data clarifying the effects of telomere shortening on cancer cells

In a previous study, we have shown that shortening of telomeres by telomerase inhibition sensitized cancer cells to cisplatinum, slower their migration, increased DNA damage and impaired DNA repair [1]. In the following study, we present a network model combining microRNA and proteomic profiling att...

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Detalles Bibliográficos
Autores principales: Uziel, Orit, Lahav, Meir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459769/
https://www.ncbi.nlm.nih.gov/pubmed/26217705
http://dx.doi.org/10.1016/j.dib.2014.12.003
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author Uziel, Orit
Lahav, Meir
author_facet Uziel, Orit
Lahav, Meir
author_sort Uziel, Orit
collection PubMed
description In a previous study, we have shown that shortening of telomeres by telomerase inhibition sensitized cancer cells to cisplatinum, slower their migration, increased DNA damage and impaired DNA repair [1]. In the following study, we present a network model combining microRNA and proteomic profiling attempting to decipher the molecular mechanism underlying the effect of shortened telomeres on the obtained phenotype of cancer cells [2]. The microRNA and proteomic data were used for a network model construction, which provided us with several nodal candidates that may potentially mediate the shortened-telomeres dependent features. These protein expressions were experimentally validated, supporting their potential central role in this system [2]. In this article, we delineate the full proteomic data and a microarray analyses performed on cells with shortened telomeres compared to their cognate parental intact telomere cells. The data is attached as excel files. In principle, clarifying the mechanism behind telomere shortened phenotype may facilitate novel therapeutics development and may also obviate the time consuming process of telomere shortening achieved by telomerase inhibition.
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spelling pubmed-44597692015-07-27 Proteomic and microRNA data clarifying the effects of telomere shortening on cancer cells Uziel, Orit Lahav, Meir Data Brief Data Article In a previous study, we have shown that shortening of telomeres by telomerase inhibition sensitized cancer cells to cisplatinum, slower their migration, increased DNA damage and impaired DNA repair [1]. In the following study, we present a network model combining microRNA and proteomic profiling attempting to decipher the molecular mechanism underlying the effect of shortened telomeres on the obtained phenotype of cancer cells [2]. The microRNA and proteomic data were used for a network model construction, which provided us with several nodal candidates that may potentially mediate the shortened-telomeres dependent features. These protein expressions were experimentally validated, supporting their potential central role in this system [2]. In this article, we delineate the full proteomic data and a microarray analyses performed on cells with shortened telomeres compared to their cognate parental intact telomere cells. The data is attached as excel files. In principle, clarifying the mechanism behind telomere shortened phenotype may facilitate novel therapeutics development and may also obviate the time consuming process of telomere shortening achieved by telomerase inhibition. Elsevier 2014-12-18 /pmc/articles/PMC4459769/ /pubmed/26217705 http://dx.doi.org/10.1016/j.dib.2014.12.003 Text en © 2014 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Uziel, Orit
Lahav, Meir
Proteomic and microRNA data clarifying the effects of telomere shortening on cancer cells
title Proteomic and microRNA data clarifying the effects of telomere shortening on cancer cells
title_full Proteomic and microRNA data clarifying the effects of telomere shortening on cancer cells
title_fullStr Proteomic and microRNA data clarifying the effects of telomere shortening on cancer cells
title_full_unstemmed Proteomic and microRNA data clarifying the effects of telomere shortening on cancer cells
title_short Proteomic and microRNA data clarifying the effects of telomere shortening on cancer cells
title_sort proteomic and microrna data clarifying the effects of telomere shortening on cancer cells
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459769/
https://www.ncbi.nlm.nih.gov/pubmed/26217705
http://dx.doi.org/10.1016/j.dib.2014.12.003
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