Cargando…

Regulation of hematogenous tumor metastasis by acid sphingomyelinase

Metastatic dissemination of cancer cells is the ultimate hallmark of malignancy and accounts for approximately 90% of human cancer deaths. We investigated the role of acid sphingomyelinase (Asm) in the hematogenous metastasis of melanoma cells. Intravenous injection of B16F10 melanoma cells into wil...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carpinteiro, Alexander, Becker, Katrin Anne, Japtok, Lukasz, Hessler, Gabriele, Keitsch, Simone, Požgajovà, Miroslava, Schmid, Kurt W, Adams, Constantin, Müller, Stefan, Kleuser, Burkhard, Edwards, Michael J, Grassmé, Heike, Helfrich, Iris, Gulbins, Erich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459814/ https://www.ncbi.nlm.nih.gov/pubmed/25851537 http://dx.doi.org/10.15252/emmm.201404571

Ejemplares similares

Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma
por: Schumacher, Fabian, et al.
Publicado: (2022)

Acid Sphingomyelinase Deficiency Ameliorates Farber Disease
por: Beckmann, Nadine, et al.
Publicado: (2019)

Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro
por: Naser, Eyad, et al.
Publicado: (2020)

Pseudomonas aeruginosa Pyocyanin Induces Neutrophil Death via Mitochondrial Reactive Oxygen Species and Mitochondrial Acid Sphingomyelinase
por: Managò, Antonella, et al.
Publicado: (2015)

Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation
por: Reichel, Martin, et al.
Publicado: (2018)

Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa
por: Pewzner-Jung, Yael, et al.
Publicado: (2014)

Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells
por: Carpinteiro, Alexander, et al.
Publicado: (2020)

Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells
por: Carpinteiro, Alexander, et al.
Publicado: (2021)

The Forebrain-Specific Overexpression of Acid Sphingomyelinase Induces Depressive-Like Symptoms in Mice
por: Zoicas, Iulia, et al.
Publicado: (2020)

Acid sphingomyelinase inhibition protects mice from lung edema and lethal Staphylococcus aureus sepsis
por: Peng, Huiming, et al.
Publicado: (2015)

Inhibition of acid sphingomyelinase by tricyclic antidepressants and analogons
por: Beckmann, Nadine, et al.
Publicado: (2014)

Sphingosine as a New Antifungal Agent against Candida and Aspergillus spp.
por: Hashemi Arani, Fahimeh, et al.
Publicado: (2022)

Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma
por: Wilson, Gregory C., et al.
Publicado: (2023)

Simultaneous targeting of mitochondrial Kv1.3 and lysosomal acid sphingomyelinase amplifies killing of pancreatic ductal adenocarcinoma cells in vitro and in vivo
por: Patel, Sameer H., et al.
Publicado: (2023)

Intestinal Acid Sphingomyelinase Protects From Severe Pathogen-Driven Colitis
por: Meiners, Jana, et al.
Publicado: (2019)

Acid Sphingomyelinase Contributes to the Control of Mycobacterial Infection via a Signaling Cascade Leading from Reactive Oxygen Species to Cathepsin D
por: Wu, Yuqing, et al.
Publicado: (2020)

Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes
por: Nojima, Hiroyuki, et al.
Publicado: (2016)

Sphingosine-1-phosphate as signaling molecule in the skin: Relevance in atopic dermatitis
por: Japtok, Lukasz, et al.
Publicado: (2014)

Repurposing antidepressants inhibiting the sphingomyelinase acid/ceramide system against COVID-19: current evidence and potential mechanisms
por: Hoertel, Nicolas, et al.
Publicado: (2021)

The acid sphingomyelinase/ceramide system in COVID-19
por: Kornhuber, Johannes, et al.
Publicado: (2021)

Neutral Sphingomyelinase in Physiological and Measles Virus Induced T Cell Suppression
por: Mueller, Nora, et al.
Publicado: (2014)

Acid sphingomyelinase deficiency enhances myelin repair after acute and chronic demyelination
por: Chami, Marwan, et al.
Publicado: (2017)

Reduced Sphingosine in Cystic Fibrosis Increases Susceptibility to Mycobacterium abscessus Infections
por: Schnitker, Fabian, et al.
Publicado: (2023)

Role of Acid Sphingomyelinase in the Regulation of Social Behavior and Memory
por: Zoicas, Iulia, et al.
Publicado: (2016)

The Anti-Infectious Role of Sphingosine in Microbial Diseases
por: Wu, Yuqing, et al.
Publicado: (2021)

Medications Modulating the Acid Sphingomyelinase/Ceramide System and 28-Day Mortality among Patients with SARS-CoV-2: An Observational Study
por: Hoertel, Nicolas, et al.
Publicado: (2023)

Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2
por: Edwards, Michael J., et al.
Publicado: (2020)

Ceramide levels in blood plasma correlate with major depressive disorder severity and its neutralization abrogates depressive behavior in mice
por: Schumacher, Fabian, et al.
Publicado: (2022)

Sphingosine 1-Phosphate Modulates Antigen Capture by Murine Langerhans Cells via the S1P(2) Receptor Subtype
por: Japtok, Lukasz, et al.
Publicado: (2012)

Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage
por: Hoehn, Richard S., et al.
Publicado: (2016)

Staphylococcus aureus α-Toxin Induces Acid Sphingomyelinase Release From a Human Endothelial Cell Line
por: Krones, David, et al.
Publicado: (2021)

Monitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass Spectrometry
por: Wigger, Dominik, et al.
Publicado: (2019)

Antimicrobial effects of inhaled sphingosine against Pseudomonas aeruginosa in isolated ventilated and perfused pig lungs
por: Carstens, Henning, et al.
Publicado: (2022)

Mitochondrial Kv1.3 Channels as Target for Treatment of Multiple Myeloma
por: Kadow, Stephanie, et al.
Publicado: (2022)

Characterization of Acid Sphingomyelinase Activity in Human Cerebrospinal Fluid
por: Mühle, Christiane, et al.
Publicado: (2013)

DC-SIGN Mediated Sphingomyelinase-Activation and Ceramide Generation Is Essential for Enhancement of Viral Uptake in Dendritic Cells
por: Avota, Elita, et al.
Publicado: (2011)

Acid sphingomyelinase deactivation post-ischemia promotes brain angiogenesis and remodeling by small extracellular vesicles
por: Mohamud Yusuf, Ayan, et al.
Publicado: (2022)

Ex vivo assay to evaluate the efficacy of drugs targeting sphingolipids in preventing SARS-CoV-2 infection of nasal epithelial cells
por: Becker, Katrin Anne, et al.
Publicado: (2021)

Role of Neutral Sphingomyelinase-2 (NSM 2) in the Control of T Cell Plasma Membrane Lipid Composition and Cholesterol Homeostasis
por: Börtlein, Charlene, et al.
Publicado: (2019)

Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis
por: Sydor, Svenja, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_2i93k4e330kf9olhrrvfrh7s1k