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Pharmacological targeting of the protein synthesis mTOR/4E-BP1 pathway in cancer-associated fibroblasts abrogates pancreatic tumour chemoresistance

Pancreatic ductal adenocarcinoma (PDAC) is extremely stroma-rich. Cancer-associated fibroblasts (CAFs) secrete proteins that activate survival and promote chemoresistance of cancer cells. Our results demonstrate that CAF secretome-triggered chemoresistance is abolished upon inhibition of the protein...

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Detalles Bibliográficos
Autores principales:	Duluc, Camille, Moatassim-Billah, Siham, Chalabi-Dchar, Mounira, Perraud, Aurélie, Samain, Rémi, Breibach, Florence, Gayral, Marion, Cordelier, Pierre, Delisle, Marie-Bernadette, Bousquet-Dubouch, Marie-Pierre, Tomasini, Richard, Schmid, Herbert, Mathonnet, Muriel, Pyronnet, Stéphane, Martineau, Yvan, Bousquet, Corinne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459815/ https://www.ncbi.nlm.nih.gov/pubmed/25834145 http://dx.doi.org/10.15252/emmm.201404346

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