ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8(+) cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy

PD-1 negatively regulates CD8(+) cytotoxic T lymphocytes (CTL) cytotoxicity and anti-tumor immunity. However, it is not fully understood how PD-1 expression on CD8(+) CTL is regulated during anti-tumor immunotherapy. In this study, we have identified that the ADAP-SKAP55 signaling module reduced CD8...

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Detalles Bibliográficos
Autores principales: Li, Chunyang, Li, Weiyun, Xiao, Jun, Jiao, Shaozhuo, Teng, Fei, Xue, Shengjie, Zhang, Chi, Sheng, Chun, Leng, Qibin, Rudd, Christopher E, Wei, Bin, Wang, Hongyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459816/
https://www.ncbi.nlm.nih.gov/pubmed/25851535
http://dx.doi.org/10.15252/emmm.201404578

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