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Vasculotide reduces endothelial permeability and tumor cell extravasation in the absence of binding to or agonistic activation of Tie2

Angiopoietin-1 (Ang1) activation of Tie2 receptors on endothelial cells (ECs) reduces adhesion by tumor cells (TCs) and limits junctional permeability to TC diapedesis. We hypothesized that systemic therapy with Vasculotide (VT)—a purported Ang1 mimetic, Tie2 agonist—can reduce the extravasation of...

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Detalles Bibliográficos
Autores principales:	Wu, Florence TH, Lee, Christina R, Bogdanovic, Elena, Prodeus, Aaron, Gariépy, Jean, Kerbel, Robert S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459817/ https://www.ncbi.nlm.nih.gov/pubmed/25851538 http://dx.doi.org/10.15252/emmm.201404193

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