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Association of vitamin D(3) with alveolar bone regeneration in dogs
Designed sockets prepared on the mandibles of nine Beagle dogs were divided into three groups: Calcitriol +Alloplast, Alloplast and Empty. Five of the nine dogs received Vit.D(3) and calcium supplement (Vit.D/Ca group), while the other four dogs without supplements were assigned to Non-Vit.D/Ca grou...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459836/ https://www.ncbi.nlm.nih.gov/pubmed/25753943 http://dx.doi.org/10.1111/jcmm.12460 |
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author | Hong, Hsiang-Hsi Yen, Tzung-Hai Hong, Adrienne Chou, Ting-An |
author_facet | Hong, Hsiang-Hsi Yen, Tzung-Hai Hong, Adrienne Chou, Ting-An |
author_sort | Hong, Hsiang-Hsi |
collection | PubMed |
description | Designed sockets prepared on the mandibles of nine Beagle dogs were divided into three groups: Calcitriol +Alloplast, Alloplast and Empty. Five of the nine dogs received Vit.D(3) and calcium supplement (Vit.D/Ca group), while the other four dogs without supplements were assigned to Non-Vit.D/Ca group. After 4 weeks, the extent of vertical ridge resorption (VRR), bone density (density), new bone formation (NBF) and implant stability quotient (ISQ) were measured. Following systemic Vit.D/Ca administration, the Empty subgroup showed significant differences from the Calcitriol + Alloplast subgroup on variants NBF/Density/VRR and the Alloplast subgroup on items NBF/Density/ISQ/VRR. Alternatively, the Calcitriol + Alloplast subgroup revealed higher values of NBF/Density/ISQ (P < 0.001) and a lower VRR value (P = 0.001) than the Alloplast subgroup. Although there were no significant differences in NBF (P = 0.349), density (P = 0.796), ISQ (P = 0.577) and VRR (0.979) comparisons on alloplast treatment between the Vit.D/Ca and Non-Vit.D/Ca groups, local application with Calcitriol + Alloplast demonstrated better NBF/Density/ISQ (P = 0.02 to <0.001) effects than which of Alloplast subgroups. Consequently, the results showed that both systemic and local vitamin D(3) treatment might accelerate bone regeneration in dogs. Within the using dose, systemic vitamin D(3) treatment displayed a superior stimulating effect than local vitamin D(3) application did. |
format | Online Article Text |
id | pubmed-4459836 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BlackWell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-44598362015-06-16 Association of vitamin D(3) with alveolar bone regeneration in dogs Hong, Hsiang-Hsi Yen, Tzung-Hai Hong, Adrienne Chou, Ting-An J Cell Mol Med Original Articles Designed sockets prepared on the mandibles of nine Beagle dogs were divided into three groups: Calcitriol +Alloplast, Alloplast and Empty. Five of the nine dogs received Vit.D(3) and calcium supplement (Vit.D/Ca group), while the other four dogs without supplements were assigned to Non-Vit.D/Ca group. After 4 weeks, the extent of vertical ridge resorption (VRR), bone density (density), new bone formation (NBF) and implant stability quotient (ISQ) were measured. Following systemic Vit.D/Ca administration, the Empty subgroup showed significant differences from the Calcitriol + Alloplast subgroup on variants NBF/Density/VRR and the Alloplast subgroup on items NBF/Density/ISQ/VRR. Alternatively, the Calcitriol + Alloplast subgroup revealed higher values of NBF/Density/ISQ (P < 0.001) and a lower VRR value (P = 0.001) than the Alloplast subgroup. Although there were no significant differences in NBF (P = 0.349), density (P = 0.796), ISQ (P = 0.577) and VRR (0.979) comparisons on alloplast treatment between the Vit.D/Ca and Non-Vit.D/Ca groups, local application with Calcitriol + Alloplast demonstrated better NBF/Density/ISQ (P = 0.02 to <0.001) effects than which of Alloplast subgroups. Consequently, the results showed that both systemic and local vitamin D(3) treatment might accelerate bone regeneration in dogs. Within the using dose, systemic vitamin D(3) treatment displayed a superior stimulating effect than local vitamin D(3) application did. BlackWell Publishing Ltd 2015-06 2015-03-08 /pmc/articles/PMC4459836/ /pubmed/25753943 http://dx.doi.org/10.1111/jcmm.12460 Text en © 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Hong, Hsiang-Hsi Yen, Tzung-Hai Hong, Adrienne Chou, Ting-An Association of vitamin D(3) with alveolar bone regeneration in dogs |
title | Association of vitamin D(3) with alveolar bone regeneration in dogs |
title_full | Association of vitamin D(3) with alveolar bone regeneration in dogs |
title_fullStr | Association of vitamin D(3) with alveolar bone regeneration in dogs |
title_full_unstemmed | Association of vitamin D(3) with alveolar bone regeneration in dogs |
title_short | Association of vitamin D(3) with alveolar bone regeneration in dogs |
title_sort | association of vitamin d(3) with alveolar bone regeneration in dogs |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459836/ https://www.ncbi.nlm.nih.gov/pubmed/25753943 http://dx.doi.org/10.1111/jcmm.12460 |
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