First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain

We report the first isolation of a voriconazole-resistant Aspergillus fumigatus strain harbouring the azole resistance mechanism TR46/Y121F/T289A, recovered from an azole-naive patient in Spain with chronic obstructive pulmonary disease. This new finding in Spain suggests the spread of this resistan...

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Autores principales: Pelaez, T., Monteiro, M.C., Garcia-Rubio, R., Bouza, E., Gomez-Lopez, A., Mellado, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
First Clinical Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459865/
https://www.ncbi.nlm.nih.gov/pubmed/26082842
http://dx.doi.org/10.1016/j.nmni.2015.04.005
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author Pelaez, T.
Monteiro, M.C.
Garcia-Rubio, R.
Bouza, E.
Gomez-Lopez, A.
Mellado, E.
author_facet Pelaez, T.
Monteiro, M.C.
Garcia-Rubio, R.
Bouza, E.
Gomez-Lopez, A.
Mellado, E.
author_sort Pelaez, T.
collection PubMed
description We report the first isolation of a voriconazole-resistant Aspergillus fumigatus strain harbouring the azole resistance mechanism TR46/Y121F/T289A, recovered from an azole-naive patient in Spain with chronic obstructive pulmonary disease. This new finding in Spain suggests the spread of this resistance mechanism and reinforces the need for antifungal susceptibility surveillance.
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spelling pubmed-44598652015-06-16 First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain Pelaez, T. Monteiro, M.C. Garcia-Rubio, R. Bouza, E. Gomez-Lopez, A. Mellado, E. New Microbes New Infect First Clinical Case Report We report the first isolation of a voriconazole-resistant Aspergillus fumigatus strain harbouring the azole resistance mechanism TR46/Y121F/T289A, recovered from an azole-naive patient in Spain with chronic obstructive pulmonary disease. This new finding in Spain suggests the spread of this resistance mechanism and reinforces the need for antifungal susceptibility surveillance. Elsevier 2015-04-20 /pmc/articles/PMC4459865/ /pubmed/26082842 http://dx.doi.org/10.1016/j.nmni.2015.04.005 Text en © 2015 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle First Clinical Case Report
Pelaez, T.
Monteiro, M.C.
Garcia-Rubio, R.
Bouza, E.
Gomez-Lopez, A.
Mellado, E.
First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain
title First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain
title_full First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain
title_fullStr First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain
title_full_unstemmed First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain
title_short First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain
title_sort first detection of aspergillus fumigatus azole-resistant strain due to cyp51a tr46/y121f/t289a in an azole-naive patient in spain
topic First Clinical Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459865/
https://www.ncbi.nlm.nih.gov/pubmed/26082842
http://dx.doi.org/10.1016/j.nmni.2015.04.005
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