Cargando…

The Population-Based Risk of Need for Coronary Revascularization According to the Presence of Type 2 Diabetes Mellitus and History of Coronary Heart Disease in the Korean Population

BACKGROUND: Whether diabetic patients without a history of coronary heart disease (CHD) have the same risk of CHD events as non-diabetic patients with a history of CHD remains controversial. This study aimed to determine whether type 2 diabetes mellitus (T2DM) is a coronary heart disease (CHD) equiv...

Descripción completa

Detalles Bibliográficos
Autores principales: Jung, Chang Hee, Seo, Gi Hyeon, Suh, Sunghwan, Bae, Ji Cheol, Kim, Mee Kyoung, Hwang, You-Cheol, Kim, Jae Hyeon, Lee, Byung-Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459959/
https://www.ncbi.nlm.nih.gov/pubmed/26053222
http://dx.doi.org/10.1371/journal.pone.0128627
_version_ 1782375291282259968
author Jung, Chang Hee
Seo, Gi Hyeon
Suh, Sunghwan
Bae, Ji Cheol
Kim, Mee Kyoung
Hwang, You-Cheol
Kim, Jae Hyeon
Lee, Byung-Wan
author_facet Jung, Chang Hee
Seo, Gi Hyeon
Suh, Sunghwan
Bae, Ji Cheol
Kim, Mee Kyoung
Hwang, You-Cheol
Kim, Jae Hyeon
Lee, Byung-Wan
author_sort Jung, Chang Hee
collection PubMed
description BACKGROUND: Whether diabetic patients without a history of coronary heart disease (CHD) have the same risk of CHD events as non-diabetic patients with a history of CHD remains controversial. This study aimed to determine whether type 2 diabetes mellitus (T2DM) is a coronary heart disease (CHD) equivalent in the need for coronary revascularization procedures (RVs) in the Korean population. METHODOLOGY/PRINCIPAL FINDINGS: We followed 2,168,698 subjects who had oral anti-diabetic drugs (OADs)-taking T2DM in 2008 and/or CHD in 2007–2008 (i.e., recent CHD). We used systematic datasets from the nationwide claims database of the Health Insurance Review and Assessment service of Korea, which is representative of the whole population of Korea, from January 2007 to December 2012. The primary study endpoint was the development of need for RVs (i.e., incident CHD) after January 2009 among three groups based on their status of T2DM and recent CHD, i.e., T2DM only, recent CHD only, and both T2DM and recent CHD. After adjustment for age and sex, patients with recent CHD only had 2.14 times the risk of incident CHD (95% CI, 2.11–2.18, P<0.001) compared with patients with T2DM only. Patients with both T2DM and recent CHD demonstrated approximately 2-fold increased risk of incident CHD compared with subjects with recent CHD only (95% CI, 1.75-1.82), while 4-fold increased risk compared with subjects with T2DM only (95% CI, 3.71-3.87). The risk of incident CHD also differed according to sex and age. CONCLUSIONS/SIGNIFICANCE: This analysis of data from the nationwide claims database revealed that T2DM did not have a recent CHD equivalent risk in the Korean population. These results suggest that an appropriate strategy for the CHD risk stratification in diabetic patients should be adopted to manage this population.
format Online
Article
Text
id pubmed-4459959
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-44599592015-06-16 The Population-Based Risk of Need for Coronary Revascularization According to the Presence of Type 2 Diabetes Mellitus and History of Coronary Heart Disease in the Korean Population Jung, Chang Hee Seo, Gi Hyeon Suh, Sunghwan Bae, Ji Cheol Kim, Mee Kyoung Hwang, You-Cheol Kim, Jae Hyeon Lee, Byung-Wan PLoS One Research Article BACKGROUND: Whether diabetic patients without a history of coronary heart disease (CHD) have the same risk of CHD events as non-diabetic patients with a history of CHD remains controversial. This study aimed to determine whether type 2 diabetes mellitus (T2DM) is a coronary heart disease (CHD) equivalent in the need for coronary revascularization procedures (RVs) in the Korean population. METHODOLOGY/PRINCIPAL FINDINGS: We followed 2,168,698 subjects who had oral anti-diabetic drugs (OADs)-taking T2DM in 2008 and/or CHD in 2007–2008 (i.e., recent CHD). We used systematic datasets from the nationwide claims database of the Health Insurance Review and Assessment service of Korea, which is representative of the whole population of Korea, from January 2007 to December 2012. The primary study endpoint was the development of need for RVs (i.e., incident CHD) after January 2009 among three groups based on their status of T2DM and recent CHD, i.e., T2DM only, recent CHD only, and both T2DM and recent CHD. After adjustment for age and sex, patients with recent CHD only had 2.14 times the risk of incident CHD (95% CI, 2.11–2.18, P<0.001) compared with patients with T2DM only. Patients with both T2DM and recent CHD demonstrated approximately 2-fold increased risk of incident CHD compared with subjects with recent CHD only (95% CI, 1.75-1.82), while 4-fold increased risk compared with subjects with T2DM only (95% CI, 3.71-3.87). The risk of incident CHD also differed according to sex and age. CONCLUSIONS/SIGNIFICANCE: This analysis of data from the nationwide claims database revealed that T2DM did not have a recent CHD equivalent risk in the Korean population. These results suggest that an appropriate strategy for the CHD risk stratification in diabetic patients should be adopted to manage this population. Public Library of Science 2015-06-08 /pmc/articles/PMC4459959/ /pubmed/26053222 http://dx.doi.org/10.1371/journal.pone.0128627 Text en © 2015 Jung et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Jung, Chang Hee
Seo, Gi Hyeon
Suh, Sunghwan
Bae, Ji Cheol
Kim, Mee Kyoung
Hwang, You-Cheol
Kim, Jae Hyeon
Lee, Byung-Wan
The Population-Based Risk of Need for Coronary Revascularization According to the Presence of Type 2 Diabetes Mellitus and History of Coronary Heart Disease in the Korean Population
title The Population-Based Risk of Need for Coronary Revascularization According to the Presence of Type 2 Diabetes Mellitus and History of Coronary Heart Disease in the Korean Population
title_full The Population-Based Risk of Need for Coronary Revascularization According to the Presence of Type 2 Diabetes Mellitus and History of Coronary Heart Disease in the Korean Population
title_fullStr The Population-Based Risk of Need for Coronary Revascularization According to the Presence of Type 2 Diabetes Mellitus and History of Coronary Heart Disease in the Korean Population
title_full_unstemmed The Population-Based Risk of Need for Coronary Revascularization According to the Presence of Type 2 Diabetes Mellitus and History of Coronary Heart Disease in the Korean Population
title_short The Population-Based Risk of Need for Coronary Revascularization According to the Presence of Type 2 Diabetes Mellitus and History of Coronary Heart Disease in the Korean Population
title_sort population-based risk of need for coronary revascularization according to the presence of type 2 diabetes mellitus and history of coronary heart disease in the korean population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459959/
https://www.ncbi.nlm.nih.gov/pubmed/26053222
http://dx.doi.org/10.1371/journal.pone.0128627
work_keys_str_mv AT jungchanghee thepopulationbasedriskofneedforcoronaryrevascularizationaccordingtothepresenceoftype2diabetesmellitusandhistoryofcoronaryheartdiseaseinthekoreanpopulation
AT seogihyeon thepopulationbasedriskofneedforcoronaryrevascularizationaccordingtothepresenceoftype2diabetesmellitusandhistoryofcoronaryheartdiseaseinthekoreanpopulation
AT suhsunghwan thepopulationbasedriskofneedforcoronaryrevascularizationaccordingtothepresenceoftype2diabetesmellitusandhistoryofcoronaryheartdiseaseinthekoreanpopulation
AT baejicheol thepopulationbasedriskofneedforcoronaryrevascularizationaccordingtothepresenceoftype2diabetesmellitusandhistoryofcoronaryheartdiseaseinthekoreanpopulation
AT kimmeekyoung thepopulationbasedriskofneedforcoronaryrevascularizationaccordingtothepresenceoftype2diabetesmellitusandhistoryofcoronaryheartdiseaseinthekoreanpopulation
AT hwangyoucheol thepopulationbasedriskofneedforcoronaryrevascularizationaccordingtothepresenceoftype2diabetesmellitusandhistoryofcoronaryheartdiseaseinthekoreanpopulation
AT kimjaehyeon thepopulationbasedriskofneedforcoronaryrevascularizationaccordingtothepresenceoftype2diabetesmellitusandhistoryofcoronaryheartdiseaseinthekoreanpopulation
AT leebyungwan thepopulationbasedriskofneedforcoronaryrevascularizationaccordingtothepresenceoftype2diabetesmellitusandhistoryofcoronaryheartdiseaseinthekoreanpopulation
AT jungchanghee populationbasedriskofneedforcoronaryrevascularizationaccordingtothepresenceoftype2diabetesmellitusandhistoryofcoronaryheartdiseaseinthekoreanpopulation
AT seogihyeon populationbasedriskofneedforcoronaryrevascularizationaccordingtothepresenceoftype2diabetesmellitusandhistoryofcoronaryheartdiseaseinthekoreanpopulation
AT suhsunghwan populationbasedriskofneedforcoronaryrevascularizationaccordingtothepresenceoftype2diabetesmellitusandhistoryofcoronaryheartdiseaseinthekoreanpopulation
AT baejicheol populationbasedriskofneedforcoronaryrevascularizationaccordingtothepresenceoftype2diabetesmellitusandhistoryofcoronaryheartdiseaseinthekoreanpopulation
AT kimmeekyoung populationbasedriskofneedforcoronaryrevascularizationaccordingtothepresenceoftype2diabetesmellitusandhistoryofcoronaryheartdiseaseinthekoreanpopulation
AT hwangyoucheol populationbasedriskofneedforcoronaryrevascularizationaccordingtothepresenceoftype2diabetesmellitusandhistoryofcoronaryheartdiseaseinthekoreanpopulation
AT kimjaehyeon populationbasedriskofneedforcoronaryrevascularizationaccordingtothepresenceoftype2diabetesmellitusandhistoryofcoronaryheartdiseaseinthekoreanpopulation
AT leebyungwan populationbasedriskofneedforcoronaryrevascularizationaccordingtothepresenceoftype2diabetesmellitusandhistoryofcoronaryheartdiseaseinthekoreanpopulation