Intermittent applied mechanical loading induces subchondral bone thickening that may be intensified locally by contiguous articular cartilage lesions

OBJECTIVES: Changes in subchondral bone (SCB) and cross-talk with articular cartilage (AC) have been linked to osteoarthritis (OA). Using micro-computed tomography (micro-CT) this study: (1) examines changes in SCB architecture in a non-invasive loading mouse model in which focal AC lesions are indu...

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Detalles Bibliográficos
Autores principales: Poulet, B., de Souza, R., Kent, A.V., Saxon, L., Barker, O., Wilson, A., Chang, Y.-M., Cake, M., Pitsillides, A.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders For The Osteoarthritis Research Society 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459965/
https://www.ncbi.nlm.nih.gov/pubmed/25655679
http://dx.doi.org/10.1016/j.joca.2015.01.012

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