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Pervasive Genotypic Mosaicism in Founder Mice Derived from Genome Editing through Pronuclear Injection
Genome editing technologies, especially the Cas9/CRISPR system, have revolutionized biomedical research over the past several years. Generation of novel alleles has been simplified to unprecedented levels, allowing for rapid expansion of available genetic tool kits for researchers. However, the issu...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4459985/ https://www.ncbi.nlm.nih.gov/pubmed/26053263 http://dx.doi.org/10.1371/journal.pone.0129457 |