Amino Acid Derivatives as Palmitoylethanolamide Prodrugs: Synthesis, In Vitro Metabolism and In Vivo Plasma Profile in Rats

Palmitoylethanolamide (PEA) has antinflammatory and antinociceptive properties widely exploited in veterinary and human medicine, despite its poor pharmacokinetics. Looking for prodrugs that could progressively release PEA to maintain effective plasma concentrations, we prepared carbonates, esters a...

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Detalles Bibliográficos
Autores principales: Vacondio, Federica, Bassi, Michele, Silva, Claudia, Castelli, Riccardo, Carmi, Caterina, Scalvini, Laura, Lodola, Alessio, Vivo, Valentina, Flammini, Lisa, Barocelli, Elisabetta, Mor, Marco, Rivara, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460047/
https://www.ncbi.nlm.nih.gov/pubmed/26053855
http://dx.doi.org/10.1371/journal.pone.0128699

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