Collagenase mRNA Overexpression and Decreased Extracellular Matrix Components Are Early Events in the Pathogenesis of Emphysema

To describe the progression of parenchymal remodeling and metalloproteinases gene expression in earlier stages of emphysema, mice received porcine pancreatic elastase (PPE) instillation and Control groups received saline solution. After PPE instillation (1, 3, 6 hours, 3 and 21 days) we measured the...

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Detalles Bibliográficos
Autores principales: Robertoni, Fabíola S. Z., Olivo, Clarice R., Lourenço, Juliana D., Gonçalves, Natália G., Velosa, Ana Paula P., Lin, Chin J., Fló, Cláudia M., Saraiva-Romanholo, Beatriz M., Sasaki, Sérgio D., Martins, Milton A., Teodoro, Walcy R., Lopes, Fernanda Degobbi T. Q. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460048/
https://www.ncbi.nlm.nih.gov/pubmed/26052708
http://dx.doi.org/10.1371/journal.pone.0129590

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