The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)

Proteolytic processing of amyloid-β precursor protein (APP) by beta-site APP cleaving enzyme 1 (BACE1) is the initial step in the production of amyloid beta (Aβ), which accumulates in senile plaques in Alzheimer’s disease (AD). Essential for this cleavage is the transport and sorting of both protein...

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Detalles Bibliográficos
Autores principales: von Einem, Bjoern, Wahler, Anke, Schips, Tobias, Serrano-Pozo, Alberto, Proepper, Christian, Boeckers, Tobias M., Rueck, Angelika, Wirth, Thomas, Hyman, Bradley T., Danzer, Karin M., Thal, Dietmar R., von Arnim, Christine A. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460050/
https://www.ncbi.nlm.nih.gov/pubmed/26053850
http://dx.doi.org/10.1371/journal.pone.0129047

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