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Alternative splicing converts STIM2 from an activator to an inhibitor of store-operated calcium channels

Store-operated calcium entry (SOCE) regulates a wide variety of essential cellular functions. SOCE is mediated by STIM1 and STIM2, which sense depletion of ER Ca(2+) stores and activate Orai channels in the plasma membrane. Although the amplitude and dynamics of SOCE are considered important determi...

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Detalles Bibliográficos
Autores principales:	Rana, Anshul, Yen, Michelle, Sadaghiani, Amir Masoud, Malmersjö, Seth, Park, Chan Young, Dolmetsch, Ricardo E., Lewis, Richard S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2015
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4460148/ https://www.ncbi.nlm.nih.gov/pubmed/26033257 http://dx.doi.org/10.1083/jcb.201412060

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